{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:22:33Z","timestamp":1762431753060,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030310319"],"award-info":[{"award-number":["2018A030310319"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802441"],"award-info":[{"award-number":["81802441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the effect of the interval between CRT and surgery on radiation proctitis, the pathologic response, and postoperative morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cohort study from a phase III, randomized controlled trial (FOWARC study, NCT01211210). Data were retrieved from the leading center of the trial. Patients were divided into the short\u2010interval (\u22647\u00a0weeks) group and the long\u2010interval (&gt;7\u00a0weeks) group. The rate of radiation proctitis, pathologic complete regression (pCR) and morbidities were calculated for each group. Multivariate analysis was used to verify the impact of interval on radiation proctitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Surgery was performed in 60 patients after an interval of \u22647\u00a0weeks and in 97 patients after an interval of &gt;7\u00a0weeks. The two groups according to interval were comparable in terms of baseline demographic and clinicotherapeutic characteristics. Radiation proctitis was identified by imaging in 9 (15.0%) patients in short\u2010interval group and in 31 (32.0%) patients in long\u2010interval group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.018). Multivariate analysis confirmed the correlation between long interval and radiation proctitis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.018). The long interval was significantly associated with longer median operation time compared to the short interval (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.022). The rates of pCR and postoperative complications were not different between two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A longer interval after CRT may be associated with higher rate of radiation proctitis and longer operation time. Moreover it did not increase the rate of pCR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2755","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T08:30:09Z","timestamp":1576139409000},"page":"912-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of interval between preoperative radiotherapy and surgery on clinical outcome and radiation proctitis in rectal cancer from FOWARC trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Yi\u2010Kan","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi\u2010Yuan","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery The Sixth Affiliated Hospital Sun Yat\u2010Sen University 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