{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:36:57Z","timestamp":1769920617700,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T00:00:00Z","timestamp":1577232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Assessment of viable tumor residue after definitive radiotherapy is essential in patients with nasopharyngeal carcinoma (NPC). This study aimed to investigate the use of Hopkins criteria on positron emission tomography\/computed tomography (PET\/CT) for posttreatment response evaluation and whether plasma Epstein\u2010Barr virus (EBV) DNA could bring additional value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>NPC patients who underwent FDG\u2010PET\/CT scan within 26\u00a0weeks after definitive radiotherapy were retrospectively reviewed. Residual disease was evaluated by Hopkins 5\u2010point score. Accuracy of Hopkins criteria before and after incorporating EBV DNA was calculated. Prognostic value for locoregional failure\u2010free survival (LRFFS) and disease\u2010free survival (DFS) was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and sixteen patients were evaluated. Median follow\u2010up time was 28.3\u00a0months (range 3.3\u201092.0\u00a0months). Residual disease was found in 19 (16.4%) patients. Overall, Hopkins criteria had high specificity (86.6%; 95% CI, 78.2%\u201092.7%) and negative prognostic value (NPV) (94.4%; 95% CI, 88.7%\u201097.3%), while sensitivity and positive prognostic value (PPV) was 73.7% (95% CI, 48.8%\u201090.9%), 51.9% (95% CI, 37.8%\u201065.6%), respectively. Posttreatment plasma EBV DNA was not predictive of residual tumor (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.272). PPV and accuracy were 50.0% (95% CI, 32.1%\u201067.9%) and 83.0% (95% CI, 73.8%\u201090.0%) after incorporating detectable EBV DNA into the scoring system. Positive PET\/CT results were significantly correlated with inferior 3\u2010year LRFFS (95.7% vs 79.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.043) and 3\u2010year DFS (84.6% vs 54.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Hopkins criteria demonstrated high NPV and specificity in posttreatment assessment, with the potential to be a reliable prognostic indicator for locoregional failure. Combining EBV DNA with PET\/CT did not improve diagnostic accuracies. PET\/CT should not be performed less than 12\u00a0weeks after treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2790","type":"journal-article","created":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T09:40:06Z","timestamp":1577266806000},"page":"1328-1334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hopkins criteria for residual disease assessment after definitive radiotherapy in nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-514X","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. 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