{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:52:44Z","timestamp":1792036364575,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In patients with indolent B\u2010cell non\u2010Hodgkin's lymphoma (B\u2010NHL), one course of low\u2010dose radiotherapy (LD\u2010RT) 2\u00a0\u00d7\u00a02\u00a0Gy is emerging as new option of therapy in palliative setting. Efficacy of LD\u2010RT when repeated remains to be determinate. This study aims to assess the efficacy of repeated LD\u2010RT given in patients with indolent B\u2010NHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>All consecutive adult patients who received two or more courses of LD\u2010RT 2\u00a0\u00d7\u00a02\u00a0Gy for indolent B\u2010NHL at Gustave Roussy institution, during the period 1990\u20102015 were retrospectively investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients received two or more courses of LD\u2010RT for indolent B\u2010NHL during the study period. The median age was 57 (range 37\u201080) years, histological types were distributed among follicular lymphoma (n\u00a0=\u00a024\u00a0pts; 73%), marginal\u2010zone lymphoma (n\u00a0=\u00a06\u00a0pts; 18%), and primary cutaneous follicle center lymphoma (n\u00a0=\u00a03\u00a0pts; 9%). The median number of low\u2010dose radiation therapy courses given per patients was 2 (range 2\u20106). The overall response rates following the first and the second course of LD\u2010RT were 96% and 88%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.31). The 1\u2010 and 2\u2010years local control rates following the first courses of LD\u2010RT were 94% (CI 95: 86\u2010100) and 94% (CI 95: 86\u201098); and were 91% (CI 95: 82\u2010100) and 88% (CI 95: 77\u2010100) following the second course of LD\u2010RT (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The repeated courses of LD\u2010RT offered similar efficacy compare with the first course in patients with indolent B\u2010NHL. LD\u2010RT repeated is a simple, easy to give, and non\u2010toxic asset that could be investigated as treatment option in patients with indolent B\u2010NHL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2796","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T07:37:58Z","timestamp":1586158678000},"page":"3725-3732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Repeated courses of low\u2010dose 2\u00a0\u00d7\u00a02\u00a0Gy radiation therapy in patients with indolent B\u2010cell non\u2010Hodgkin lymphomas"],"prefix":"10.1002","volume":"9","author":[{"given":"Khalil","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Hematology Gustave Roussy Universit\u00e9 Paris\u2010Saclay Villejuif 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