{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:27:10Z","timestamp":1791894430513,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Health and Welfare of"},{"DOI":"10.13039\/501100009879","name":"Emilia-Romagna Region","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009879","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Up to 10% of individuals with breast cancer (BC) belong to families with hereditary syndromes. The aim of this study was to develop an instrument to identify individuals\/families at high\u2010hereditary risk for BC and offer dedicated surveillance programs according to different risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The instrument consisted of a primary questionnaire collecting history of BC and ovarian cancer (OC). This questionnaire was applied to women enrolled in the Emilia\u2010Romagna Breast Cancer Screening Program. General practitioners (GPs) and specialists could propose the same questionnaire too. Women with a score of\u00a0\u2265\u00a02, were invited to complete an oncogenetic counseling. According to the Tyrer\u2010Cuzick evaluation, women considered at high risk were invited to involve the most representative alive individual of the family affected with BC\/OC for <jats:italic>BRCA1\/2<\/jats:italic> genetic testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Since January 2012 and December 2016, 660\u00a0040 women were evaluated by the regional screening program, of which 22\u00a0289 (3.5%) were invited to the Spoke evaluation, but only 5615 accepted (25.2%). Totally, also considering women sent by GPs and specialists, 11\u00a0667 were assessed and 5554 were sent to the Hub evaluation. Finally, 2342 (42.8%) women fulfilled the criteria for genetic testing, and 544 (23.2%) resulted <jats:italic>BRCA1\/2<\/jats:italic> mutation carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this is the first regional population\u2010based multistep model that is aimed to identify individuals\u00a0with <jats:italic>BRCA1\/2<\/jats:italic> mutations and to offer an intensive surveillance program for hereditary\u2010high risk women. This tool is feasible and effective, even if more efforts must be performed to increase the acceptance of multiple assessments by the study population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2824","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T16:46:46Z","timestamp":1581439606000},"page":"2579-2589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A regional population\u2010based hereditary breast cancer screening tool in Italy: First 5\u2010year results"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8950-8561","authenticated-orcid":false,"given":"Laura","family":"Cortesi","sequence":"first","affiliation":[{"name":"Department of Oncology and Haematology Azienda Ospedaliero Universitaria di Modena Ospedale Civile di Baggiovara Modena 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