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Currently, valid prognostic biomarkers in DLBCL are still lacking. To optimize targeted therapy and improve the prognosis of DLBCL, the performance of proposed biomarkers needs to be evaluated in multiple cohorts, and new biomarkers need to be investigated in large datasets. Here, we developed a consensus <jats:bold><jats:styled-content>O<\/jats:styled-content><\/jats:bold>nline <jats:bold><jats:styled-content>S<\/jats:styled-content><\/jats:bold>urvival analysis web server for <jats:bold>D<\/jats:bold>iffuse <jats:bold>L<\/jats:bold>arge <jats:bold>B<\/jats:bold>\u2010<jats:bold>C<\/jats:bold>ell <jats:bold>L<\/jats:bold>ymphoma, abbreviated <jats:bold>OSdlbcl<\/jats:bold>, to assess the prognostic value of individual gene. To build OSdlbcl, we collected 1100 samples with gene expression profiles and clinical follow\u2010up information from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. In addition, DNA mutation data were also collected from the TCGA database. Overall survival (OS), progression\u2010free survival (PFS), disease\u2010specific survival (DSS), disease\u2010free interval (DFI), and progression\u2010free interval (PFI) are important endpoints to reflect the survival rate in OSdlbcl. Moreover, clinical features were integrated into OSdlbcl to allow data stratifications according to the user's special needs. By inputting an official gene symbol and selecting desired criteria, the survival analysis results can be graphically presented by the Kaplan\u2010Meier (KM) plot with hazard ratio (HR) and log\u2010rank <jats:italic>p<\/jats:italic> value. As a proof\u2010of\u2010concept demonstration, the prognostic value of 23 previously reported survival associated biomarkers, such as transcription factors <jats:italic>FOXP1<\/jats:italic> and <jats:italic>BCL2<\/jats:italic>, was evaluated in OSdlbcl and found to be significantly associated with survival as reported (HR\u00a0=\u00a01.73, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01; HR\u00a0=\u00a01.47, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03, respectively). In conclusion, OSdlbcl is a new web server that integrates public gene expression, gene mutation data, and clinical follow\u2010up information to provide prognosis evaluations for biomarker development for DLBCL. The OSdlbcl web server is available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/bioinfo.henu.edu.cn\/DLBCL\/DLBCLList.jsp\">https:\/\/bioinfo.henu.edu.cn\/DLBCL\/DLBCLList.jsp<\/jats:ext-link>.<\/jats:p>","DOI":"10.1002\/cam4.2829","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T23:59:24Z","timestamp":1578614364000},"page":"1790-1797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["OSdlbcl: An online consensus survival analysis web server based on gene expression profiles of diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-2168","authenticated-orcid":false,"given":"Huan","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Predictive Medicine, Institute of Biomedical Informatics Cell Signal Transduction Laboratory Bioinformatics Center Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Software School of Basic Medical Sciences Henan University Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Predictive Medicine, Institute of Biomedical Informatics Cell Signal Transduction Laboratory Bioinformatics Center Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Software School of Basic Medical Sciences Henan University Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guosen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Predictive Medicine, Institute of Biomedical Informatics Cell Signal Transduction Laboratory Bioinformatics Center Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Software School of Basic Medical Sciences Henan University Kaifeng 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Institute of Biomedical Informatics Cell Signal Transduction Laboratory Bioinformatics Center Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Software School of Basic Medical Sciences Henan University Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longxiang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Predictive Medicine, Institute of Biomedical Informatics Cell Signal Transduction Laboratory Bioinformatics Center Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Software School of Basic Medical Sciences Henan University Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Predictive Medicine, Institute of Biomedical Informatics Cell Signal Transduction Laboratory Bioinformatics Center Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Software School of Basic Medical Sciences Henan University Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Predictive Medicine, Institute of Biomedical Informatics Cell Signal Transduction Laboratory Bioinformatics Center Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Software School of Basic Medical Sciences Henan University Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuchun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine Stanford CA 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