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The data used for this analysis are from the linked Surveillance, Epidemiology, and End\u2010Results (<jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content>)\u2010Medicare database. The retrospective cohort study included women aged 66\u00a0years and older with stage 0\u2013III breast cancer diagnosed between 2000 and 2005. Women were grouped as low, intermediate, or high cardiovascular risk based on the presence of certain clinical diagnoses. The risk for the combined outcome of a hospitalization for a cardiovascular event or death within 6\u00a0months and 24\u00a0months of diagnosis was estimated using a multivariable Cox model. The median follow\u2010up time was 24\u00a0months. Among the 91,612 women with American Joint Committee on Cancer (<jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content>) stage 0\u2013III breast cancer: 39,555 (43.2%) were treated with radiation therapy and 52,057 (56.8%) were not. The receipt of radiation therapy in the first 6\u00a0months was associated with a statistically significant increased risk for the combined outcome in women categorized as high risk (HR\u00a0=\u00a01.510; 95% CI, 1.396\u20131.634) or intermediate risk (HR\u00a0=\u00a01.415; 95% CI, 1.188\u20131.686) but not low risk (HR\u00a0=\u00a01.027; 95% CI, 0.798\u20131.321). Women with a prior medical history of cardiovascular disease treated with radiation therapy are at increased risk for an event and should be monitored for at least 6\u00a0months following treatment with radiation therapy.<\/jats:p>","DOI":"10.1002\/cam4.283","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T05:31:21Z","timestamp":1404970281000},"page":"1342-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cardiovascular event\u2010free survival after adjuvant radiation therapy in breast cancer patients stratified by cardiovascular risk"],"prefix":"10.1002","volume":"3","author":[{"given":"Nneka C.","family":"Onwudiwe","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Health Services Research University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberechukwu","family":"Onukwugha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Health Services Research University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Sorkin","sequence":"additional","affiliation":[{"name":"Geriatrics Research, Education and Clinical Center Baltimore VA Medical Center Baltimore Maryland"},{"name":"Division of Gerontology and Geriatric Medicine Department of Medicine University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilene H.","family":"Zuckerman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Health Services Research University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadia T.","family":"Shaya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Health Services Research University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Daniel Mullins","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Health Services Research University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050518"},{"key":"e_1_2_7_3_1","volume-title":"SEER cancer statistics review, 1975\u20132010","author":"Howlader N.","year":"2013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2901"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq683"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk064"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.1.37"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391407"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502093320607"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504063321402"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306033282202"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00271-J"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61629-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022152"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.6595"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70251-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.4.1348"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(98)00062-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji067"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2625"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.193"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.04.042"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1033"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133187.74800.B9"},{"key":"e_1_2_7_27_1","unstructured":"Surveillance Epidemiology and End Results. 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