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The proliferation, migration, and invasion of PTC cells were determined after knockdown or overexpression of CASC9 to evaluate the effect of CASC9 on PTC cells. Also, the role of PTC tumorigenesis was confirmed in mice xenograft models. Additionally, the underlying mechanisms of CASC9 were further researched. We found that CASC9 expression was augmented in human PTC tissues and cells. Higher CASC9 expression was associated with large tumor size, advanced stage, or lymph node metastasis. Downregulation of CASC9 significantly attenuated the proliferative, migrative, and invasive abilities of PTC cells, and suppressed tumorigenesis in vivo. While overexpression of CASC9 elevated the proliferation, migration, and invasion of PTC cells. miR\u2010488\u20103p expression was decreased, and ADAM9 level was increased in PTC tissues and cells. CASC9 expression was negatively related to miR\u2010488\u20103p, but positively associated with ADAM9 expression in PTC tissues. Molecular mechanism analysis revealed that CASC9 functioned via sponging miR\u2010488\u20103p to regulate ADAM9 expression, followed by activation of EGFR\u2010Akt signaling. In conclusion, lncRNA CASC9 promoted the malignant phenotypes of PTC via modulating miR\u2010488\u20103p\/ADAM9 pathway. This study may provide a novel therapeutic target for the treatment of PTC.<\/jats:p>","DOI":"10.1002\/cam4.2839","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T04:01:05Z","timestamp":1578974465000},"page":"1830-1841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["RETRACTED: Long noncoding RNA CASC9 promotes the proliferation and metastasis of papillary thyroid cancer via sponging miR\u2010488\u20103p"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0179-2372","authenticated-orcid":false,"given":"Yonghui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine Beijing 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