{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:50:44Z","timestamp":1790419844307,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770128"],"award-info":[{"award-number":["81770128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To explore the risk factors of thrombosis in patients with\n                    <jats:italic>\n                      JAK2\n                      <jats:sup>V617F<\/jats:sup>\n                      \u2010\n                    <\/jats:italic>\n                    mutated myeloproliferative neoplasms (MPNs), a cohort of 1537 Chinese patients with\n                    <jats:italic>\n                      JAK2\n                      <jats:sup>V617F<\/jats:sup>\n                    <\/jats:italic>\n                    \u2010mutated MPN was retrospectively analyzed. The Kaplan\u2010Meier method and multivariate Cox analysis were used to study the risk factors of thrombosis in patients with\n                    <jats:italic>\n                      JAK2\n                      <jats:sup>V617F<\/jats:sup>\n                    <\/jats:italic>\n                    \u2010mutated MPN. Among the 1537 MPN patients, 931, 468, and 138 had polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), respectively. The median follow\u2010up time was 7\u00a0years (range 1\u201047), and 12.8% of patients (197\/1537) died during this period. A total of 16.8% (259\/1399) of PV and ET patients had secondary myelofibrosis, and 2.5% (38\/1537) of patients developed acute myeloid leukemia (AML). Thrombotic events occurred in 43.9% (675\/1537) of patients, among which 91.4% (617\/675) were arterial thrombosis and 16.6% (112\/675) were venous thrombosis. The number of thrombotic events in PV, ET, and PMF patients was 439 (47.2%), 197 (42.1%) and 39 (28.2%), respectively. The multivariate analysis indicated that age \u226560\u00a0years old, HCT \u226548%, at least one cardiovascular risk factor, a history of thrombosis, and\n                    <jats:italic>\n                      JAK2\n                      <jats:sup>V617F<\/jats:sup>\n                    <\/jats:italic>\n                    allele burden (\n                    <jats:italic>V617F<\/jats:italic>\n                    %) \u226550% are risk factors for thrombosis in\n                    <jats:italic>\n                      JAK2\n                      <jats:sup>V617F<\/jats:sup>\n                    <\/jats:italic>\n                    \u2010mutated MPN. According to the results of the multivariate analysis, a risk model of thrombosis was established and comprised low\u2010risk (0 points), intermediate\u2010risk (1 points) and high\u2010risk (\u22652 points) groups, among which the incidence of thrombosis was 9.1%, 33.7% and 72.9%. For elderly patients with\n                    <jats:italic>\n                      JAK2\n                      <jats:sup>V617F<\/jats:sup>\n                    <\/jats:italic>\n                    \u2010mutated MPN and a history of thrombosis, reducing the\n                    <jats:italic>V617F%<\/jats:italic>\n                    , controlling HCT and preventing cardiovascular risk factors are necessary measures to prevent thrombosis.\n                  <\/jats:p>","DOI":"10.1002\/cam4.2886","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T23:58:26Z","timestamp":1580255906000},"page":"2096-2105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Thrombosis among 1537 patients with\n                    <i>\n                      JAK2\n                      <sup>V617F<\/sup>\n                    <\/i>\n                    \u2010mutated myeloproliferative neoplasms: Risk factors and development of a predictive model"],"prefix":"10.1002","volume":"9","author":[{"given":"Yuhui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Institute of Hematology &amp; Blood Diseases Hospital National Clinical Research Center for Blood Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingshao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University Tianjin China"},{"name":"State Key Laboratory of Experimental Hematology Institute of Hematology &amp; Blood Diseases Hospital National Clinical Research Center for Blood Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangshuai","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Institute of Hematology &amp; Blood Diseases Hospital National Clinical Research Center for Blood Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University Tianjin 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