{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:57:17Z","timestamp":1785844637308,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570569"],"award-info":[{"award-number":["81570569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572451"],"award-info":[{"award-number":["81572451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672888"],"award-info":[{"award-number":["81672888"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1604168"],"award-info":[{"award-number":["U1604168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Nicotinamide n\u2010methyltransferase (NNMT) has good biochemical activity and epigenetic regulation, and has been reported as a major metabolic regulator of cancer. The goal of this study was to investigate the significance of stromal NNMT expression in colorectal cancer (CRC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Stromal expression of NNMT in primary CRC, metastasis CRC, and their non\u2010cancerous tissues from 1088 CRC patients was examined by immunohistochemistry. The associations between stromal NNMT expression and survival outcomes in 967 patients with stage I\u2010III CRC were further evaluated with Kaplan\u2010Meier curve and Cox model analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NNMT expression was mainly sourced from stromal compartments and also elevated in CRC. Patients with high stromal NNMT (IHC\u2010score\u00a0\u2265\u00a0106) have a worse survival than those patients with low stromal NNMT. In multiple Cox analyses, high expression of stromal NNMT remained as an independent risk factor in CRC for disease\u2010free survival with a hazard ratio (HR) of 1.415 (95% confidence interval [CI], 1.015\u20101.972) and disease\u2010specific survival with a HR of 5.004 (95% CI, 2.301\u201010.883). In addition, high stromal NNMT expression in CRC also indicates the poor survival outcomes in patients with early stage CRC (stage I and II) and in patients who undergo chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NNMT is mainly located in CRC stromal compartment. High stromal NNMT expression predicts an unfavorable postoperative prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2890","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T03:44:14Z","timestamp":1580183054000},"page":"2030-2038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["High stromal nicotinamide N\u2010methyltransferase (NNMT) indicates poor prognosis in colorectal cancer"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0258-3935","authenticated-orcid":false,"given":"Mengmeng","family":"Song","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Statistics College of Public Health Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Digestive Endoscopy Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyong","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuao","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanping","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Beijing Shijitan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6028-5923","authenticated-orcid":false,"given":"Chunhua","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics College of Public Health Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"issue":"20","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"14835","DOI":"10.1016\/S0021-9258(17)36700-5","article-title":"Human liver nicotinamide N\u2010methyltransferase","volume":"269","author":"Aksoy S","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1323"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(99)00139-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1173-8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9962"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.08.017"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000430"},{"issue":"3","key":"e_1_2_5_9_1","first-page":"649","article-title":"Nicotinamide N\u2010methyltransferase: a potential biomarker for worse prognosis in gastric carcinoma","volume":"6","author":"Chen C","year":"2016","journal-title":"Am J Cancer Res"},{"issue":"15","key":"e_1_2_5_10_1","first-page":"19975","article-title":"Expression profile and prognostic value of NNMT in patients with pancreatic cancer","volume":"7","author":"Yong XU","year":"2015","journal-title":"Oncotarget"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu174"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-28-20"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0983"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2012-0112"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-012-9451-1"},{"issue":"1","key":"e_1_2_5_16_1","first-page":"94","article-title":"Clinical performance and utility of a NNMT\u2010based urine test for bladder cancer","volume":"33","author":"Pozzi V","year":"2018","journal-title":"J Exp Clinic Cancer Res"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3224"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts588"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxp059"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305475"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70318-7"},{"issue":"6","key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1158\/1055-9965.EPI-18-1066","article-title":"A High monocyte\u2010to\u2010lymphocyte ratio predicts poor prognosis in patients with advanced gallbladder cancer receiving chemotherapy","volume":"28","author":"Choi YH","year":"2019","journal-title":"Cancer Epidem Biomar Prevention"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.140"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486770"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29072"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.3426"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.086"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.2890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.2890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.2890","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.2890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:01:03Z","timestamp":1694048463000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.2890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,27]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/cam4.2890"],"URL":"https:\/\/doi.org\/10.1002\/cam4.2890","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,27]]},"assertion":[{"value":"2019-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}