{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:56:28Z","timestamp":1778162188984,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30\u2010CA093373"],"award-info":[{"award-number":["P30\u2010CA093373"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10\u2010CA180886"],"award-info":[{"award-number":["U10\u2010CA180886"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180819"],"award-info":[{"award-number":["U10CA180819"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180888"],"award-info":[{"award-number":["U10CA180888"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1\u2010CA189955"],"award-info":[{"award-number":["UG1\u2010CA189955"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA189805"],"award-info":[{"award-number":["UG1CA189805"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few adolescents and young adults (AYAs, 15\u201039\u00a0years old) enroll onto cancer clinical trials, which hinders research otherwise having the potential to improve outcomes in this unique population. Prior studies have reported that AYAs are more likely to receive cancer care in community settings. The National Cancer Institute (NCI) has led efforts to increase trial enrollment through its network of NCI\u2010designated cancer centers (NCICC) combined with community outreach through its Community Clinical Oncology Program (CCOP; replaced by the NCI Community Oncology Research Program in 2014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using AYA proportional enrollment (the proportion of total enrollments who were AYAs) as the primary outcome, we examined enrollment of AYAs onto SWOG therapeutic trials at NCICC, CCOP, and non\u2010NCICC\/non\u2010CCOP sites from 2004 to 2013 by type of site, study period (2004\u201008 vs 2009\u201013), and patient demographics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, AYA proportional enrollment was 10.1%. AYA proportional\u00a0enrollment decreased between 2004\u20102008 and 2009\u20102013 (13.1% vs 8.5%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and was higher at NCICCs than at CCOPs and non\u2010NCICC\/non\u2010CCOPs (14.1% vs 8.3% and 9.2%, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). AYA proportional enrollment declined significantly at all three site types. Proportional enrollment of AYAs who were Black or Hispanic was significantly higher at NCICCs compared with CCOPs or non\u2010NCICC\/non\u2010CCOPs (11.5% vs 8.8, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.048 and 11.5% vs 8.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Not only did community sites enroll a lower proportion of AYAs onto cancer clinical trials, but AYA enrollment decreased in all study settings. Initiatives aimed at increasing AYA enrollment, particularly in the community setting with attention to minority status, are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.2891","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T09:56:03Z","timestamp":1580723763000},"page":"2146-2152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-8353","authenticated-orcid":false,"given":"Michael E.","family":"Roth","sequence":"first","affiliation":[{"name":"Division of Pediatrics The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Unger","sequence":"additional","affiliation":[{"name":"SWOG Cancer Research Network Statistics and Data Management Center Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann M.","family":"O'Mara","sequence":"additional","affiliation":[{"name":"Community Oncology and Prevention Trials Research Group Division of Cancer Prevention National Cancer Institute Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Intermountain Health Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy","family":"Budd","sequence":"additional","affiliation":[{"name":"Community Oncology and Prevention Trials Research Group Division of Cancer Prevention National Cancer Institute Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca H.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Mary Bridge Children's Hospital and Health Center and Tacoma General Hospital Tacoma WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad H.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences and the UC Davis Comprehensive Cancer Center University of California Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Blanke","sequence":"additional","affiliation":[{"name":"Southwest Oncology Group Chair's Office and Knight Cancer Center Institute Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5280-990X","authenticated-orcid":false,"given":"David R.","family":"Freyer","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine Cancer and Blood Diseases Institute Children's Hospital Los Angeles USC Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkz031"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29669"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0122D"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31127"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000318"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23060"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2015.009084"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0265"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26638"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3558-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.14694\/EDBK_156686"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2011.09.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.23.1945"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.22.236"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25248"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2012.12.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.2954"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.4103"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-011-0173-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0122C"},{"key":"e_1_2_9_23_1","first-page":"17","article-title":"Patterns of care among adolescents with malignancy in Ohio","volume":"28","author":"Yeager ND","year":"2006","journal-title":"J Pediatr Hematol Oncol"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.3628"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-466706"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju300"},{"key":"e_1_2_9_27_1","unstructured":"ColbySL OrtmanJM.Projections of the size and composition of the US population: 2014 to 2060: Population estimates and projections.2017."},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29067"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2015.07.012"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.2891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.2891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.2891","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.2891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:01:09Z","timestamp":1694048469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.2891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,3]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/cam4.2891"],"URL":"https:\/\/doi.org\/10.1002\/cam4.2891","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,3]]},"assertion":[{"value":"2020-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}