{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:26:27Z","timestamp":1791757587492,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to update a previous scoring system for patients with skeletal metastases, that was proposed by Katagiri et\u00a0al. in 2005, by introducing a new factor (laboratory data) and analyzing a new patient cohort. Between January 2005 and January 2008, we treated 808 patients with symptomatic skeletal metastases. They were prospectively registered regardless of their treatments, and the last follow\u2010up evaluation was performed in 2012. There were 441 male and 367 female patients with a median age of 64\u00a0years. Of these patients, 749 were treated nonsurgically while the remaining 59 underwent surgery for skeletal metastasis. A multivariate analysis was conducted using the Cox proportional hazards model. We identified six significant prognostic factors for survival, namely, the primary lesion, visceral or cerebral metastases, abnormal laboratory data, poor performance status, previous chemotherapy, and multiple skeletal metastases. The first three factors had a larger impact than the remaining three. The prognostic score was calculated by adding together all the scores for individual factors. With a prognostic score of \u22657, the survival rate was 27% at 6\u00a0months, and only 6% at 1\u00a0year. In contrast, patients with a prognostic score of \u22643 had a survival rate of 91% at 1\u00a0year, and 78% at 2\u00a0years. Comparing the revised system with the previous one, there was a significantly lower number of wrongly predicted patients using the revised system. This revised scoring system was able to predict the survival rates of patients with skeletal metastases more accurately than the previous system and may be useful for selecting an optimal treatment.<\/jats:p>","DOI":"10.1002\/cam4.292","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T01:07:02Z","timestamp":1404954422000},"page":"1359-1367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":388,"title":["New prognostic factors and scoring system for patients with skeletal metastasis"],"prefix":"10.1002","volume":"3","author":[{"given":"Hirohisa","family":"Katagiri","sequence":"first","affiliation":[{"name":"Division of Orthopaedic Oncology Shizuoka Cancer Center Hospital Nagaizumi Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rieko","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Nagoya University, Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Takagi","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Oncology Shizuoka Cancer Center Hospital Nagaizumi Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Oncology Shizuoka Cancer Center Hospital Nagaizumi Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Murata","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Oncology Shizuoka Cancer Center Hospital Nagaizumi Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Harada","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Shizuoka Cancer Center Hospital Nagaizumi Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Shizuoka Cancer Center Hospital Nagaizumi Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Asakura","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Shizuoka Cancer Center Hospital Nagaizumi Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Shizuoka Cancer Center Hospital Nagaizumi Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2006.02.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.754"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.0542"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00443814"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B12.16629"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200102010-00016"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000180401.06919.a5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679508995508"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20756"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23888"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B5.15185"},{"key":"e_1_2_6_13_1","first-page":"116","volume-title":"Orthopaedic management of metastatic bone disease","author":"Harrington K. 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