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Aldehyde dehydrogenase 1 (<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>1) has been recognized as a marker of<jats:styled-content style=\"fixed-case\">CIC<\/jats:styled-content>s. We previously reported that<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>1\u2010high cases of uterine endometrioid adenocarcinoma showed poor prognosis, and that<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>1 high population was more tumorigenic, invasive, and resistant to apoptosis than<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>1 low population. Histamine plays a critical role in cancer cell proliferation, migration, and invasion. Here, we examined the effect of histamine on<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>1 expression in endometrioid adenocarcinoma cell line. The addition of histamine increased<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>1 high population, which was consistent with the result that histamine enhanced the invasive ability and the resistance to anticancer drug. Among 4 types of histamine receptors, histamine H1 and H2 receptor (H1R and H2R) were expressed in endometrioid adenocarcinoma cell line. The addition of H1R agonist but not H2R agonist increased<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>1. The antagonist H1R but not H2R inhibited the effect of histamine on<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>1 expression. These results indicated that histamine increased the expression of<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>1 via H1R but not H2R. These findings may provide the evidence for exploring a new strategy to suppress<jats:styled-content style=\"fixed-case\">CIC<\/jats:styled-content>s by inhibiting<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>1 expression with histamine.<\/jats:p>","DOI":"10.1002\/cam4.296","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T05:50:46Z","timestamp":1404971446000},"page":"1126-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line"],"prefix":"10.1002","volume":"3","author":[{"given":"Yi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Yamada\u2010oka 2\u20102 Suita 565\u20100871 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Yamada\u2010oka 2\u20102 Suita 565\u20100871 Japan"},{"name":"Department of Pathology Harbin Medical University of China 157 Baojian Road, Harbin Heilongjiang 150081 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010ichiro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Yamada\u2010oka 2\u20102 Suita 565\u20100871 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Yamada\u2010oka 2\u20102 Suita 565\u20100871 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Applied Quantum Medical Engineering School of Engineering Tohoku University 6\u20106\u201002\u20103 Aramaki\u2010aza, Aoba Sendai 980\u20108579 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohtsu","sequence":"additional","affiliation":[{"name":"Department of Applied Quantum Medical Engineering School of Engineering Tohoku University 6\u20106\u201002\u20103 Aramaki\u2010aza, Aoba Sendai 980\u20108579 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Morii","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Yamada\u2010oka 2\u20102 Suita 565\u20100871 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000232264"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00395-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1585"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2004.06.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00961.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-8056-4_11"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01969974"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05424.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.04.049"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01993160"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)90666-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e328347ee53"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01674409"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.10.30"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(97)92388-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)90153-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-7404(94)90046-9"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0031-6997(24)01328-0","article-title":"International Union of Pharmacology. 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