{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:47:19Z","timestamp":1788871639252,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Grant-in-Aid for Cancer Research from the Ministry of Education, Culture, Sports, Science","award":["22240093"],"award-info":[{"award-number":["22240093"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pleural mesothelioma is an aggressive tumor, commonly caused by exposure to asbestos. The prognosis of mesothelioma remains disappointing despite multimodal treatment. We reported previously that N\u2010\n                    <jats:styled-content style=\"fixed-case\">ERC<\/jats:styled-content>\n                    \/mesothelin could be a useful biomarker for the early diagnosis of pleural mesothelioma and developed an enzyme\u2010linked immunosorbent assay (\n                    <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                    ) system for its detection. However, the reproducibility of our previous 7\u201316\n                    <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                    system has been revealed to be unsatisfactory. To measure N\u2010\n                    <jats:styled-content style=\"fixed-case\">ERC<\/jats:styled-content>\n                    \/mesothelin more precisely, we developed a new 7\u201320\n                    <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                    system. The subjects of this study were patients who were referred to our department with suspected pleural mesothelioma. The current study demonstrated that the newly established 7\u201320\n                    <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                    system improved the sensitivity and specificity for diagnosing pleural mesothelioma compared with the previous system. Moreover, the 7\u201320\n                    <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                    system showed better reproducibility and displayed the tendency of both higher sensitivity and higher specificity in plasma than in serum. Particularly for the epithelioid type, the area under the curve (AUC) and the diagnostic accuracy of N\u2010\n                    <jats:styled-content style=\"fixed-case\">ERC<\/jats:styled-content>\n                    \/mesothelin were excellent; the AUC was 0.91, the sensitivity was 0.95, and the specificity was 0.76 in plasma. In conclusion, assessment of N\u2010\n                    <jats:styled-content style=\"fixed-case\">ERC<\/jats:styled-content>\n                    \/mesothelin with our newly established 7\u201320\n                    <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                    system is clinically useful for the precise diagnosis of pleural mesothelioma.\n                  <\/jats:p>","DOI":"10.1002\/cam4.297","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T01:44:46Z","timestamp":1404956686000},"page":"1377-1384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Newly established\n                    <scp>ELISA<\/scp>\n                    for N\u2010\n                    <scp>ERC<\/scp>\n                    \/mesothelin improves diagnostic accuracy in patients with suspected pleural mesothelioma"],"prefix":"10.1002","volume":"3","author":[{"given":"Tadashi","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Graduate School of Medicine 2\u20101\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20108421 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Graduate School of Medicine 2\u20101\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20108421 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Graduate School of Medicine 2\u20101\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20108421 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Maeda","sequence":"additional","affiliation":[{"name":"Immuno\u2010Biological Laboratories Co., Ltd. 1091\u20101 Naka Fujioka Gunma 375\u20100005 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncology Juntendo University Graduate School of Medicine 2\u20101\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20108421 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okio","family":"Hino","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncology Juntendo University Graduate School of Medicine 2\u20101\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20108421 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Graduate School of Medicine 2\u20101\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20108421 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70469-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.3943"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00039510"},{"key":"e_1_2_7_6_1","first-page":"2971","article-title":"Cyfra 21\u20101 and TPA as markers in malignant mesothelioma","volume":"17","author":"Bonfrer J. 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