{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:45:20Z","timestamp":1779003920040,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Philadelphia chromosome\u2010negative (Ph\u2212) myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal disorders of the bone marrow, and are associated with a high disease burden, reduced quality of life (QOL), and shortened survival. This multinational, multicenter, non\u2010interventional registry \u201cMERGE\u201d was initiated with an objective to collect data on the epidemiological indices of classical Ph\u2010MPNs, existing treatment patterns, and impact of MPNs on health\u2010related QOL in various countries\/regions in Asia, including the Middle East, Turkey, and Algeria. Of the 884 eligible patients with MPNs, 169 had myelofibrosis (MF), 301 had polycythemia vera (PV), 373 had essential thrombocythemia (ET), and 41 had unclassified MPNs. The median age was 58\u00a0years (range, 47\u201066\u00a0years), and 50% of patients were males. The prevalence and incidence of MPNs were estimated to be 57\u201081 and 12\u201015 per 100\u00a0000 hospital patients per year over the last 4\u00a0years, respectively, in these countries. Total symptom score (mean [standard deviation; SD]) at baseline was highest in patients with MF (23.5 [17.47]) compared with patients with ET (14.6 [14.26]) and PV (16.6 [14.84]). Patients with ET had a lower mean (SD) number of inpatient visits (0.9 [0.77] days), and patients with MF had more outpatient visits (5.2 [3.17] days) on an average, compared with the entire MPN group. The study showed that patients with MPNs have a severe disease burden and reduced QOL. A discordance between physician and patient perception of symptom assessment was observed in this study\u00a0(International clinical\u00a0trials registry ID: CTRI\/2014\/05\/004598).<\/jats:p>","DOI":"10.1002\/cam4.3004","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T14:31:01Z","timestamp":1588257061000},"page":"4512-4526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["MERGE: A Multinational, Multicenter Observational Registry for Myeloproliferative Neoplasms in Asia, including Middle East, Turkey, and Algeria"],"prefix":"10.1002","volume":"9","author":[{"given":"Mohamed A.","family":"Yassin","sequence":"first","affiliation":[{"name":"National Center for Cancer Care and Research Hamad Medical Corporation Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-2238","authenticated-orcid":false,"given":"Ali","family":"Taher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9417-2353","authenticated-orcid":false,"given":"Vikram","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010An","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahir","family":"Shamsi","sequence":"additional","affiliation":[{"name":"Research Department National Institute of Blood Disease and Bone Marrow Transplantation Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fclin Firatli","family":"Tu\u011flular","sequence":"additional","affiliation":[{"name":"Department of Hematology Marmara University Hospital \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-7385","authenticated-orcid":false,"given":"Zhijian","family":"Xiao","sequence":"additional","affiliation":[{"name":"MDS and MPN Centre Institute of Hematology &amp; Blood Diseases Hospital CAMS and PUMC Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Depei","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Hospital Affiliated to Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junmin","family":"Li","sequence":"additional","affiliation":[{"name":"Ruijin Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Rippin","sequence":"additional","affiliation":[{"name":"IQVIA\u2122 Neu\u2010Isenburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam","family":"Sadek","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation East Hanover NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Novartis AG Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9011-4268","authenticated-orcid":false,"given":"Raymond S.","family":"Wong","sequence":"additional","affiliation":[{"name":"Sir YK Pao Centre for Cancer &amp; Department of Medicine and Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3082-y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2015.06.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.3863"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2208-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22365"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-328955"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1365852"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.3117.3117"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/26.4.404"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209262"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2016.31.10.1579"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12788"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.05.024"},{"key":"e_1_2_10_16_1","volume-title":"SEER Cancer Statistics Review, 1975\u20132015","author":"Noone AM","year":"2018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.092155"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-485888"},{"key":"e_1_2_10_19_1","first-page":"322","article-title":"Results from the 208\u2010week (4\u2010year) follow\u2010up of RESPONSE trial, a phase 3 study comparing ruxolitinib (Rux) with best available therapy (BAT) for the treatment of polycythemia vera (PV)","volume":"130","author":"Kiladjian J\u2010J","year":"2017","journal-title":"Blood"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.813500"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12256"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.12.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.89"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.11.001"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.3004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.3004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T13:30:37Z","timestamp":1734701437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.3004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":23,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/cam4.3004"],"URL":"https:\/\/doi.org\/10.1002\/cam4.3004","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]},"assertion":[{"value":"2019-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}