{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:57:03Z","timestamp":1761562623596,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Science and Technology Program of Guangzhou, China","award":["805223205082"],"award-info":[{"award-number":["805223205082"]}]},{"name":"the Dean Research Funding of Nanfang Hospital, Southern Medical University, China","award":["2016B018"],"award-info":[{"award-number":["2016B018"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether prognosis differs between lung acinar predominant adenocarcinoma (ACN) and papillary predominant adenocarcinoma (PAP) patients remains controversial. Furthermore, the appropriate surgical plan for each subtype is undetermined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of stage I ACN or PAP patients from 2004 to 2015 were retrospectively reviewed by SEER*Stat 8.3.5. The primary outcome was overall survival (OS) and lung cancer specific survival (LCSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1531 patients (PAP, 484; ACN, 1047) were included. ACN patients had better OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and LCSS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003) than PAP patients. Among stage I ACN patients, lobectomy with mediastinal lymph node dissection (Lob) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) or segmentectomy (Seg) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003) provided a better OS than wedge resection (Wed). And ACN patients who received Lob had a equivalent LCSS, compared to those who received Seg (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.895). For patients with PAP in stage I, those who received Lob tended to have a better prognosis than that received Seg (HR of OS, 0.605, 95% CI: 0.263\u20101.393; HR of LCSS, 0.541, 95% CI: 0.194\u20101.504) or Wed (HR of OS, 0.735, 95% CI: 0.481\u20101.123; HR of LCSS, 0.688, 95% CI: 0.402\u20101.180).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with lung adenocarcinoma in stage I, those with ACN have a better OS and LCSS than that with PAP. For patients with stage I ACN, Seg and Lob, rather than Wed, seem to be an equivalent treatment choice; however, Seg is the prior option because it could preserve more lung function than Lob. For patients with PAP, Lob tends to be a better choice than Wed and Seg, although the prognostic difference between them is nonsignificant.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3012","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T12:44:53Z","timestamp":1585053893000},"page":"3455-3462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinicopathological features, survival outcomes, and appropriate surgical approaches for stage I acinar and papillary predominant lung adenocarcinoma"],"prefix":"10.1002","volume":"9","author":[{"given":"Di","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nanfang Hospital 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