{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:07:46Z","timestamp":1783627666248,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2018-1-2151"],"award-info":[{"award-number":["2018-1-2151"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The treatment outcomes and prognosis of lymphoma are affected by various factors such as hospital types. This study was to describe the temporal trend in the survival of lymphoma in an academic center in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 3840 consecutive patients with lymphoma diagnosed between 1996 and 2015 were reviewed. Eighty patients were excluded, and finally, 3760 patients were analyzed in this study. The cohort was divided into four groups according to calendar periods at diagnosis: 1996\u20102000, 2001\u20102005, 2006\u20102010, and 2010\u20102015. The overall survival (OS) rates among the four groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010 and 10\u2010year OS for the whole cohort were 62% and 52%, respectively. The 5\u2010year OS of patient with classic Hodgkin lymphoma (cHL), mature B\u2010cell lymphoma (BCL), and peripheral T\u2010cell lymphoma (PTCL) were 79%, 63%, and 50%, respectively. Among mature BCL, the 5\u2010year OS was highest in follicular lymphoma (77.8%), followed by Burkitt lymphoma (76.5%), marginal zone lymphoma (74.1%), diffuse large B\u2010cell lymphoma (61.5%), small lymphocytic lymphoma\/chronic lymphocytic leukemia (55.1%), and mantle cell lymphoma (44.3%). Among PTCL, the 5\u2010year OS was highest in ALK+anaplastic large cell lymphoma (79.0%), followed by ALK\u2212anaplastic large cell lymphoma (63.1%), natural killer\/T\u2010cell lymphoma (57.7%), angioimmunoblastic T\u2010cell lymphoma (34.9%, and peripheral T\u2010cell lymphoma not otherwise specified (27.6%). Significant improvement in the survival of lymphoma was observed, with the 5\u2010year OS increasing from 48% in 1996\u20102000 to 65% in 2011\u20102015 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The 5\u2010year OS of patients with cHL, mature BCL, and PTCL changed from 55%, 49%, and 41% in 1996\u20102000 to 79%, 65%, and 51% in 2011\u20102015, respectively (<jats:italic>P<\/jats:italic> values were .014, .002, and .592, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The survival of most types of lymphoma such as cHL and mature BCL, rather than PTCL, was improved significantly during the past two decades.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3037","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T05:39:21Z","timestamp":1586756361000},"page":"3765-3774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Improving survival of 3760 patients with lymphoma: Experience of an academic center over two decades"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-1411","authenticated-orcid":false,"given":"Weiping","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqiang","family":"Ji","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Medical Record Statistics Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5451-6481","authenticated-orcid":false,"given":"Yuqin","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningjing","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifeng","family":"Tu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Ping","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Ying","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feier","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Leng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-2547","authenticated-orcid":false,"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Lymphoma Peking University Cancer Hospital &amp; Institute Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0706-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21357"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30127-X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5094"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33326-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1839"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60278-5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620715592568"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0785-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15639"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2019.1598678"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2016.11.004"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21722"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70235-2"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.237401"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq582"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/11591160-000000000-00000"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000486"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.34175"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0117"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv201"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30416"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.186577"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-018-3744-z"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.23067"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31821"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-278796"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.3037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.3037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T02:00:28Z","timestamp":1693965628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.3037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,12]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/cam4.3037"],"URL":"https:\/\/doi.org\/10.1002\/cam4.3037","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,12]]},"assertion":[{"value":"2019-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}