{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:01:14Z","timestamp":1781305274282,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Immune Design Corp.,\u00a0a wholly-owned subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Outcomes data regarding advanced synovial sarcoma (SS) and myxoid\/round cell liposarcoma (MRCL) are limited, consisting primarily of retrospective series and post hoc analyses of clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multi\u2010center retrospective study, data were abstracted from the medical records of 350 patients from nine sarcoma centers throughout the United States and combined into a registry. Patients with advanced\/unresectable or metastatic SS (n\u00a0=\u00a0249) or MRCL (n\u00a0=\u00a0101) who received first\u2010line systemic anticancer therapy and had records of tumor imaging were included. Overall survival (OS), time to next treatment, time to distant metastasis, and progression\u2010free survival (PFS) were evaluated using the Kaplan\u2010Meier method and Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At start of first\u2010line systemic anticancer therapy, 92.4% of patients with SS and 91.1% of patients with MRCL had metastatic lesions. However, 74.7% of patients with SS and 72.3% of patients with MRCL had \u22652 lines of systemic therapy. Median OS and median PFS from first\u2010line therapy for SS was 24.7\u00a0months (95% CI, 20.9\u201029.4) and 7.5\u00a0months, respectively (95% CI, 6.4\u20108.4). Median OS and median PFS from start of first\u2010line therapy for MRCL was 29.9\u00a0months (95% CI, 27\u201044.6) and 8.9\u00a0months (95% CI 4.5\u201012.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To the best of our knowledge, this is the largest retrospective study of patients with SS and MRCL. It provides an analysis of real\u2010world clinical outcomes among patients treated at major sarcoma cancer centers and could inform treatment decisions and design of clinical trials. In general, the survival outcomes for this selected population appear more favorable than in published literature.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3039","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T12:39:42Z","timestamp":1588768782000},"page":"4593-4602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinical outcomes of patients with advanced synovial sarcoma or myxoid\/round cell liposarcoma treated at major cancer centers in the United States"],"prefix":"10.1002","volume":"9","author":[{"given":"Seth M.","family":"Pollack","sequence":"first","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0146-7732","authenticated-orcid":false,"given":"Neeta","family":"Somaiah","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejka M.","family":"Araujo","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Druta","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4572-6668","authenticated-orcid":false,"given":"Brian A.","family":"Van Tine","sequence":"additional","affiliation":[{"name":"Washington University Alvin J. 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