{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:45:10Z","timestamp":1792183510464,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["CER 1310\u201006543"],"award-info":[{"award-number":["CER 1310\u201006543"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["HHSA29020050040I"],"award-info":[{"award-number":["HHSA29020050040I"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are uncertainties about prostate cancer\u2010related anxiety's (PCRA) associations with health\u2010related quality of life (HRQOL) and major depression, and these could affect the quality of mental healthcare provided to prostate cancer patients. Addressing these uncertainties will provide more insight into PCRA and inform further research on the value of PCRA prevention. The goals of this study were to measure associations between PCRA and HRQOL at domain and subdomain levels, and to evaluate the association between PCRA and probable (ie, predicted major) depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We analyzed secondary cross\u2010sectional data from the <jats:italic>North Carolina Prostate Cancer Comparative Effectiveness &amp; Survivorship Study<\/jats:italic> (NC ProCESS\u2014a population\u2010based cohort of prostate cancer patients enrolled shortly after diagnosis [between January 2011 and June 2013] and followed prospectively). Patient\u2010reported measures of PCRA and HRQOL from 1,016 enrollees who participated in NC ProCESS\u2019s 1\u2010year follow\u2010up survey were assessed. Outcomes of interests were a) linear correlations between contemporaneous memorial anxiety scale for prostate cancer (MAX\u2010PC) and Short Form 12 (SF\u201012) scores, and b) measures of association between indicators of clinically significant PCRA (ie, MAX\u2010PC\u00a0&gt;\u00a027) and probable depression during survey contact (ie, SF\u201012 mental component score\u00a0\u226443).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PCRA measures had notable associations with SF\u201012\u2019s <jats:italic>mental health<\/jats:italic> subscale (assesses low mood\/nervousness [<jats:italic>rho<\/jats:italic>\u00a0=\u00a0\u22120.42]) and <jats:italic>emotional role functioning<\/jats:italic> subscale (assesses subjective productivity loss [<jats:italic>rho<\/jats:italic>\u00a0=\u00a0\u22120.46]). Additionally, the risk of probable depression was significantly higher in participants with clinically significant PCRA compared with those without it (weighed risk ratio\u00a0=\u00a05.3, 95% confidence interval 3.6\u20107.8; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prostate cancer patients with clinically significant PCRA should be assessed for major depression and productivity loss.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3069","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T05:45:02Z","timestamp":1587707102000},"page":"4467-4473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Associations between prostate cancer\u2010related anxiety and health\u2010related quality of life"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-7640","authenticated-orcid":false,"given":"Daniel O.","family":"Erim","sequence":"first","affiliation":[{"name":"HEOR Modeling and Advanced Analytics Parexel International Durham NC USA"},{"name":"Department of Health Policy and Management The University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia V.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management The University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"Lineberger Comprehensive Cancer Center School of Medicine The University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley N.","family":"Gaynes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry  School of Medicine The University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram S.","family":"Basak","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology  School of Medicine The University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Usinger","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center School of Medicine The University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Chen","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center School of Medicine The University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"Department of Radiation Oncology  School of Medicine The University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"Department of 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