{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:58:12Z","timestamp":1781870292824,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773547"],"award-info":[{"award-number":["81773547"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited studies have compared the association between various physical measurements and the risk of cancer or cardiovascular disease (CVD). We aim to explore the best\u2010individualized indicators of cancer and CVD risk assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From May 2004 to December 2017, a community\u2010based cohort in China involving 100\u00a0280 participants were enrolled. BMI, height, body surface area (BSA), and body fat percentage (BFP) were compared in parallel about cancer and CVD risk with the multivariable\u2010adjusted Cox proportional hazard regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within the follow\u2010up period, 3107 (3.10%) were diagnosed with cancer and 3721 (3.71%) had CVD. Per\u2010level increased (in tertile: T1, T2, and T3 level) BSA, height, and BFP was positively associated with the risk of overall cancer [HR (95% CI): 1.10 (1.05\u20101.15), 1.12 (1.07\u20101.18), and 1.10 (1.03\u20101.16), respectively], whereas BMI was insignificant. Compared with the reference group (T2), the highest BSA level (T3) was positively associated with overall cancer incidence for both male [HR (95% CI): 1.28 (1.13\u20101.45)] and female [HR (95% CI): 1.13 (1.00\u20101.28)]. The BSA, height, and BFP also significantly associated with some site\u2010specific cancers including thyroid, stomach, breast, urinary system, and skin cancer. Meanwhile, BFP presented a strong positive association with overall CVD [HR (95% CI): 1.22 (1.15\u20101.30) in trend] in both gender and associated with nearly all CVD subtypes especially the myocardial infarction and heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BSA, height, and BFP have more sensitivity in assessing cancer risk and BFP shows the largest hazard ratios for CVD incident. We provided valuable evidence for the application of height, BSA, and BFP in routine healthcare practice. These encouraging findings should be tested in more well\u2010defined studies for risk prediction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3076","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T05:24:36Z","timestamp":1588051476000},"page":"4433-4446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Body surface area, height, and body fat percentage as more sensitive risk factors of cancer and cardiovascular disease"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9858-7089","authenticated-orcid":false,"given":"Shucheng","family":"Si","sequence":"first","affiliation":[{"name":"Department of Biostatistics School of Public Health Cheeloo College of Medicine Shandong University Jinan Shandong P.R. 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