{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:08:57Z","timestamp":1774534137267,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570128"],"award-info":[{"award-number":["81570128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81820108004"],"award-info":[{"award-number":["81820108004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult patients with relapsed or refractory T\u2010cell acute lymphoblastic leukemia (R\/R\u2010T\u2010ALL) have extremely poor prognosis, representing an urgent unmet medical need. Finding an optimal salvage regimen to bridge transplantation is a priority. The CAG (cytarabine, aclarubicin, and G\u2010CSF) regimen was initially used by one group in China, showing unexpectedly promising results in 11 R\/R\u2010T\u2010ALL patients. Here, we report the multicenter results of 41 patients who received the CAG regimen as salvage therapy. After one cycle of the CAG regimen, complete remission and partial remission were achieved in 33 (80.5%) and two (4.9%) patients, respectively. Failure to respond was observed in six patients (14.6%). Early T\u2010cell precursor (ETP) (n\u00a0=\u00a026) and non\u2010ETP (n\u00a0=\u00a015) patients had a similar CR rate (80.8% vs 80.0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.95). Among 41 patients, allo\u2010HSCT was successfully performed in 27 (66%) patients (22 in CR and 5 in non\u2010CR). With a median follow\u2010up time of 12\u00a0months, the estimated 2\u2010year overall survival and event\u2010free survival were 68.8% (95% CI, 47.3%\u201083.0%) and 56.5% (95% CI, 37.1%\u201071.9%), respectively. The CAG regimen was well\u2010tolerated, and no early death occurred. Our multicenter results show that the CAG regimen is highly effective and safe, representing a novel choice for adult patients with R\/R\u2010T\u2010ALL and providing a better bridge to transplantation.<\/jats:p>","DOI":"10.1002\/cam4.3079","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T16:36:38Z","timestamp":1591202198000},"page":"5327-5334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["CAG regimen for refractory or relapsed adult T\u2010cell acute lymphoblastic leukemia: A retrospective, multicenter, cohort study"],"prefix":"10.1002","volume":"9","author":[{"given":"Jie\u2010Jing","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China"},{"name":"Institute of Hematology Zhejiang University Zhejiang China"},{"name":"Zhejiang Province Key Laboratory of Hematology 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Treatment Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-4007","authenticated-orcid":false,"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology Shanghai Changzheng Hospital The Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China"},{"name":"Institute of Hematology Zhejiang University Zhejiang China"},{"name":"Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China"},{"name":"Institute of Hematology Zhejiang University Zhejiang China"},{"name":"Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Bin","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China"},{"name":"Institute of Hematology Zhejiang University Zhejiang China"},{"name":"Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juying","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China"},{"name":"Institute of Hematology Zhejiang University Zhejiang China"},{"name":"Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China"},{"name":"Institute of Hematology Zhejiang University Zhejiang China"},{"name":"Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin\u2010Jun","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China"},{"name":"Institute of Hematology Zhejiang University Zhejiang China"},{"name":"Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010Shun","family":"You","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China"},{"name":"Institute of Hematology Zhejiang University Zhejiang China"},{"name":"Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology Changhai Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China"},{"name":"Institute of Hematology Zhejiang University Zhejiang China"},{"name":"Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Zhejiang China"},{"name":"Institute of Hematology Zhejiang University Zhejiang China"},{"name":"Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Hong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hematology Shulan (Hangzhou) Hospital Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Zhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of hematology Shaoxing Central Hospital Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Yan 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