{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T14:40:27Z","timestamp":1786804827515,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T00:00:00Z","timestamp":1590796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Helsinn Healthcare"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>NEPA is the only fixed combination antiemetic, comprised of an NK<jats:sub>1<\/jats:sub>RA (netupitant) and a 5\u2010HT<jats:sub>3<\/jats:sub>RA (palonosetron). In the first head\u2010to\u2010head trial to compare NK<jats:sub>1<\/jats:sub>RA\u2010containing regimens, a single oral dose of NEPA was non\u2010inferior to a 3\u2010day aprepitant\/granisetron (APR\/GRAN) regimen for the primary endpoint of overall (0\u2010120\u00a0hours) complete response (no emesis\/no rescue). This pre\u2010specified analysis evaluates the efficacy of NEPA versus APR\/GRAN in the subset of Chinese patients in the study. In addition, efficacy in patients at greatest emetic risk receiving high\u2010dose cisplatin (\u226570\u00a0mg\/m<jats:sup>2<\/jats:sup>) was explored. Chemotherapy\u2010na\u00efve patients with solid tumors in this randomized, double\u2010blind study received either a single dose of NEPA prior to cisplatin\u2010based chemotherapy or a 3\u2010day regimen of APR\/GRAN, both with dexamethasone on Days 1\u20104. Efficacy was evaluated through complete response, no emesis, and no significant nausea rates during the acute (0\u201024\u00a0hours), delayed (25\u2010120\u00a0hours) and overall phases as well as individual days post\u2010chemotherapy, as the daily course of CINV protection is often unstudied. The Chinese subset included 667 patients; of these, 363 (54%) received high\u2010dose cisplatin. Baseline characteristics were comparable. While response rates were similar for NEPA and APR\/GRAN during the acute, delayed and overall phases, significantly fewer NEPA patients experienced breakthrough CINV on individual Days 3\u20105 in both the Chinese patients and also in those receiving high\u2010dose cisplatin. As a fixed oral NK<jats:sub>1<\/jats:sub>RA\/5HT<jats:sub>3<\/jats:sub>RA combination given once\/cycle, NEPA is a convenient highly effective prophylactic antiemetic that may offer better protection from CINV than a 3\u2010day APR\/GRAN regimen on Days 3\u20105 following highly emetogenic chemotherapy.<\/jats:p>","DOI":"10.1002\/cam4.3123","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T09:42:33Z","timestamp":1590831753000},"page":"5134-5142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of NEPA, a fixed antiemetic combination of netupitant and palonosetron, vs a 3\u2010day aprepitant regimen for prevention of chemotherapy\u2010induced nausea and vomiting (CINV) in Chinese patients receiving highly emetogenic chemotherapy (HEC) in a randomized Phase 3 study"],"prefix":"10.1002","volume":"9","author":[{"given":"Jianhua","family":"Chang","sequence":"first","affiliation":[{"name":"Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Tumour Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Changsha Central Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Feng","sequence":"additional","affiliation":[{"name":"Jiangsu Cancer Hospital Nanjing Medical University Affiliated Cancer Hospital Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"West China School of Medicine West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Lanzarotti","sequence":"additional","affiliation":[{"name":"Helsinn Healthcare Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Chessari","sequence":"additional","affiliation":[{"name":"Helsinn Healthcare Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6672-4808","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1515442"},{"key":"e_1_2_9_3_1","unstructured":"ASCO 50th anniversary poll names top 5 advances past 50 years. The ASCO Post October 15 2014."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds021"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2012.000816"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.4789"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw270"},{"key":"e_1_2_9_8_1","unstructured":"National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology: Antiemesis [v1.2019]. Available at:https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/antiemesis.pdf. Accessed August 2019."},{"key":"e_1_2_9_9_1","article-title":"Guidelines of Chinese Society of Clinical Oncology (CSCO): prevention & treatment of nausea and vomiting caused by antitumor therapies","author":"Chen Y","year":"2019","journal-title":"People's Medical Publishing House"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80109-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.08.049"},{"key":"e_1_2_9_12_1","volume-title":"US Prescribing information","author":"Akynzeo\u00ae (netupitant and palonosetron) capsules; Akynzeo\u00ae (fosnetupitant and palonosetron) for injection","year":"2020"},{"key":"e_1_2_9_13_1","volume-title":"EU Prescribing Information","author":"Akynzeo\u00ae (netupitant\/palonosetron) capsules","year":"2020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu110"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3502-x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu096"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx698"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0737-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(05)80075-9"},{"issue":"12","key":"e_1_2_9_21_1","first-page":"1845","article-title":"Dose\u2010response relationships of the objective and subjective antiemetic effects and of different side effects of metoclopramide against cisplatin induced emesis","volume":"36","author":"Hellenbrecht D","year":"1986","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-003-0482-4"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-2043-9"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.095"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.050"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00035-2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00034-0"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.3123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.3123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T23:18:45Z","timestamp":1693955925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.3123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,30]]},"references-count":26,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/cam4.3123"],"URL":"https:\/\/doi.org\/10.1002\/cam4.3123","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,30]]},"assertion":[{"value":"2020-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}