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We systematically reviewed safety and efficacy of carbon\u2010ion radiotherapy (CIRT) for treating MMs. Eleven studies were eligible for review, and the data showed that MM patients showed better local control with low recurrence and mild toxicities after CIRT. Survival rates were slightly higher in patients with cutaneous or uveal MMs than in those with mucosal MMs. CIRT in combination with chemotherapy produced higher progression\u2010free survival rates than CIRT only. In younger patients, higher rates of distant metastases of gynecological MMs were observed. 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