{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:08:41Z","timestamp":1779894521856,"version":"3.53.1"},"reference-count":43,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000163","name":"Pediatric Oncology Group of Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hodgkin lymphoma (HL) is a common adolescent and young adult (AYA) cancer. While outcome disparities between pediatric vs. adult centers [locus of care (LOC)] have been demonstrated in other AYA cancers such as acute lymphoblastic leukemia, they have not been well studied in HL. We therefore compared population\u2010based treatment patterns and outcomes in AYA HL by LOC. The IMPACT Cohort includes data on all Ontario, Canada AYA (15\u201021\u00a0years) diagnosed with HL between 1992 and 2012. Linkage to population\u2010based health administrative data identified late effects. We examined LOC\u2010based differences in treatment modalities, cumulative doses, event\u2010free survival (EFS), overall survival (OS), and late effects. Among 954 AYA, 711 (74.5%) received therapy at adult centers. Pediatric center AYA experienced higher rates of radiation therapy but lower cumulative doses of doxorubicin and bleomycin. 10\u2010year EFS did not differ between pediatric vs. adult cancer vs. community centers (83.8%\u00a0\u00b1\u00a02.4% vs. 82.8%\u00a0\u00b1\u00a01.6% vs. 82.7%\u00b13.0%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.71); LOC was not significantly associated with either EFS or OS in multivariable analyses. Higher incidences of second malignancies in pediatric center AYA and of cardiovascular events in adult center AYA were observed, but were not significant. In conclusion, while pediatric and adult centers used different treatment strategies, outcomes were equivalent. Differences in treatment exposures are however likely to result in different late\u2010effect risks. Protocol choice should be guided by individual late\u2010effect risk.<\/jats:p>","DOI":"10.1002\/cam4.3138","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T10:19:03Z","timestamp":1590142743000},"page":"6933-6945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Treatment patterns and outcomes in adolescents and young adults with Hodgkin lymphoma in pediatric versus adult centers: An IMPACT Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-3670","authenticated-orcid":false,"given":"Sumit","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children Toronto ON Canada"},{"name":"Faculty of Medicine University of Toronto Toronto ON Canada"},{"name":"Cancer Research Program Institute for Clinical Evaluative Sciences Toronto ON Canada"},{"name":"Institute for Health 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Canada"},{"name":"Princess Margaret Cancer Centre Toronto ON Canada"},{"name":"Pediatric Oncology Group of Ontario Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Punnett","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children Toronto ON Canada"},{"name":"Faculty of Medicine University of Toronto Toronto ON Canada"},{"name":"Institute for Health Policy, Evaluation and Management University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0320-6042","authenticated-orcid":false,"given":"Rinku","family":"Sutradhar","sequence":"additional","affiliation":[{"name":"Cancer Research Program Institute for Clinical Evaluative Sciences Toronto ON Canada"},{"name":"Institute for Health Policy, Evaluation and Management University of Toronto Toronto ON Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Pole","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"},{"name":"Pediatric Oncology Group of Ontario Toronto ON Canada"},{"name":"Center for Health Services The University of Queensland Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenthila","family":"Nagamuthu","sequence":"additional","affiliation":[{"name":"Cancer Research Program Institute for Clinical Evaluative Sciences Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Lau","sequence":"additional","affiliation":[{"name":"Cancer Research Program Institute for Clinical Evaluative Sciences Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Division of 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