{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:38:15Z","timestamp":1747147095302,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T00:00:00Z","timestamp":1593302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human T\u2010lymphotropic virus\u20101 (HTLV\u20101)<jats:sup>+<\/jats:sup> Hodgkin lymphoma (HL) is difficult to differentiate from adult T\u2010cell leukemia\/lymphoma (ATLL) with HL\u2010like histology (HL\u2010like ATLL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cytological and immunohistological features, HTLV\u20101 proviral DNA integration, and rearrangements of the T\u2010cell receptor (TCR) <jats:italic>C\u03b21<\/jats:italic> gene were examined in 11 HTLV\u20101<jats:sup>+<\/jats:sup> patients with HL\u2010like disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six patients were classified as HTLV\u20101<jats:sup>+<\/jats:sup> HL and five as HL\u2010like ATLL in accordance with genetic findings of HTLV\u20101 proviral DNA integration and rearrangements of the TCR <jats:italic>C\u03b21<\/jats:italic> gene. Small ordinary looking lymphocytes with round nuclei were detected in the background of six patients with HTLV\u20101<jats:sup>+<\/jats:sup> HL, which were immunohistochemically negative for CD25 and CC chemokine receptor (CCR)4 and had a low MIB1 labeling index (mean: 28.3%). In the HL\u2010like ATLL specimens, small\u2010 and medium\u2010sized atypical lymphocytes with indented and irregular\u2010shaped nuclei were found, and were diffusely positive for CD25 and CCR4, with high MIB1 labeling (mean: 76%). Both groups had scattered CD30<jats:sup>+<\/jats:sup> and CD15<jats:sup>+<\/jats:sup> Hodgkin and Reed Sternberg (RS) giant cells, with or without CD20 expression and Epstein\u2010Barr virus infection. The 50% overall survival period was significantly longer for the HTLV\u20101<jats:sup>+<\/jats:sup> HL group (180\u00a0months) than for the HL\u2010like ATLL group (7.8\u00a0months; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HTLV\u20101<jats:sup>+<\/jats:sup> HL showed typical small lymphoid cells with a low MIB1 labeling index in a background of Hodgkin and RS cells, with some scattered CD25<jats:sup>+<\/jats:sup> and CCR4<jats:sup>+<\/jats:sup> lymphocytes. In HTLV\u20101 endemic areas, distinguishing HTLV\u20101<jats:sup>+<\/jats:sup> HL from HL\u2010like ATLL is important because of their differing treatment strategies and prognoses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3139","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T05:16:20Z","timestamp":1593407780000},"page":"5788-5797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and cytopathological characteristics of HTLV\u20101<sup>+<\/sup> hodgkin lymphoma"],"prefix":"10.1002","volume":"9","author":[{"given":"Katsumi","family":"Kobata","sequence":"first","affiliation":[{"name":"Division of Diagnostic Pathology Faculty of Medicine Fukuoka University Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Departments of Pathology Faculty of Medicine Fukuoka University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Mihashi","sequence":"additional","affiliation":[{"name":"Departments of Pathology Faculty of Medicine Fukuoka University Fukuoka Japan"},{"name":"Departments of Otolaryngology Faculty of Medicine Fukuoka University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-272X","authenticated-orcid":false,"given":"Hiromi","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Departments of Hematology National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Departments of Pathology National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1566-4681","authenticated-orcid":false,"given":"Shinji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Faculty of Medicine Fukuoka University Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Hematology and Infectious Diseases Faculty of Medicine Fukuoka University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilseung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Hematology National Hospital Organization Kyushu Cancer Center Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Kawauchi","sequence":"additional","affiliation":[{"name":"Departments of Pathology National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-497X","authenticated-orcid":false,"given":"Kenji","family":"Ishitsuka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine Kagoshima University Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0267-2081","authenticated-orcid":false,"given":"Morishige","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Faculty of Medicine Fukuoka University Hospital Fukuoka Japan"},{"name":"Departments of Pathology Faculty of Medicine Fukuoka University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,28]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"363","volume-title":"Adult T\u2010cell leukemia\/lymphoma. 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