{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:27:41Z","timestamp":1782210461649,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670152"],"award-info":[{"award-number":["81670152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770168"],"award-info":[{"award-number":["81770168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Platelet transfusion is important in the prevention and treatment of bleeding in patients with acute myeloid leukemia (AML) after receiving intensive chemotherapy. However, platelet transfusion refractoriness (PTR) is an intractable clinical issue occurred in these patients. And its clinical and immunological features remain largely unknown. The potential causes and clinical features of PTR were retrospectively analyzed in 560 patients who were diagnosed as de novo AML in Tongji Hospital from June 2012 through June 2018. A high\u2010throughput antibody screening for the detection of human leukocyte antigen (HLA) and its serotypes was performed in 133 newly diagnosed AML patients. PTR occurred in 11.8% of the de novo AML patients. The median age for patients with PTR was 46\u00a0years (range, 15\u201070). It frequently manifested in female patients and in patients with splenomegaly, M4 subtype, <jats:italic>c\u2010Kit<\/jats:italic> gene mutation, and rearrangements of <jats:italic>RUNX1\u2010RUNX1T1<\/jats:italic> or <jats:italic>CBFB\u2010MYH11<\/jats:italic>, commonly referred to as core binding factor AML (CBF\u2010AML). Notably, CBF\u2010AML was independently associated with the occurrence of PTR. PTR predominantly developed in patients who had CBF\u2010AML (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and in patients who further had better minimal residual disease (MRD) reduction (\u22653\u2010log) before the second consolidation chemotherapy (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.007). HLA\u2010I antibodies were detected in the serum of 9.0% of AML patients and markedly enriched in patients with PTR (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and in patients with CBF\u2010AML (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.018). HLA\u2010B was the most frequently identified serum epitope in PTR patients. Patients with CBF\u2010AML had higher tendency to develop HLA\u2010I antibodies and PTR, which depicted novel features of PTR in AML and might provide insights into its efficient managements.<\/jats:p>","DOI":"10.1002\/cam4.3140","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T08:44:39Z","timestamp":1589791479000},"page":"4941-4948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical and immunological features of platelet transfusion refractoriness in young patients with de novo acute myeloid leukemia"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-728X","authenticated-orcid":false,"given":"Xuelian","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Lishui City People's Hospital Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0373-6924","authenticated-orcid":false,"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengju","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-3232","authenticated-orcid":false,"given":"Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12073"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07189.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2017.08.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2724"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.05.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000465510"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(00)80007-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2006.05.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqy121"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3168-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2012.01852.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13597"},{"issue":"2","key":"e_1_2_9_14_1","first-page":"247","article-title":"A mini\u2010review on platelet refractoriness","volume":"90","author":"Rebulla P","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04468.x"},{"issue":"6","key":"e_1_2_9_16_1","first-page":"721","article-title":"Acute myeloid leukemia, version 3.2019, NCCN clinical practice guidelines","volume":"17","author":"Tallman MS","year":"2019","journal-title":"Oncology"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0203-RA"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31347"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-2002-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.150953"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15056"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03048.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02589.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02703.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12412"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12369"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2000.7920108.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-462879"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0414-2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-435669"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402504"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04684.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04085.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2014.895922"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2013.789842"},{"issue":"8","key":"e_1_2_9_36_1","first-page":"14080","article-title":"Efficiency of treatment with rituximab in platelet transfusion refractoriness: a study of 7 cases","volume":"8","author":"Liu W","year":"2015","journal-title":"Int J Clin Exp Med"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.3140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.3140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T23:17:31Z","timestamp":1693955851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.3140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,18]]},"references-count":35,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/cam4.3140"],"URL":"https:\/\/doi.org\/10.1002\/cam4.3140","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,18]]},"assertion":[{"value":"2019-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}