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They include approximately 1000 species with a diverse variety of commensal microbes that play crucial roles in the health status of individuals. Epidemiological studies related to molecular pathology have revealed that there is a close relationship between oral microbiota and tumor occurrence. Oral microbiota has attracted considerable attention for its role in in\u2010situ or distant tumor progression. Anaerobic oral bacteria with potential pathogenic abilities, especially <jats:italic>Fusobacterium nucleatum<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic>, are well studied and have close relationships with various types of carcinomas. Some aerobic bacteria such as <jats:italic>Parvimonas<\/jats:italic> are also linked to tumorigenesis. Moreover, human papillomavirus, oral fungi, and parasites are closely associated with oropharyngeal carcinoma. Microbial dysbiosis, colonization, and translocation of oral microbiota are necessary for implementation of carcinogenic functions. Various underlying mechanisms of oral microbiota\u2010induced carcinogenesis have been reported including excessive inflammatory reaction, immunosuppression of host, promotion of malignant transformation, antiapoptotic activity, and secretion of carcinogens. 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