{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:31:01Z","timestamp":1789155061641,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peripheral T\u2010cell lymphoma (PTCL) represents a heterogeneous and rare subgroup of aggressive lymphomas that generally demonstrate poor clinical outcomes with conventional treatment. Since the prognosis of PTCL is heterogeneous, more accurate risk assessment, and risk\u2010adapted treatment strategies are required. In this study, we examined whether interim positron emission tomography (iPET)\u2010computed tomography (PET\/CT) results can be combined with baseline volume\u2010based metabolic assessments including total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) for risk stratification in PTCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of 63 patients with nodal PTCL, who had analyzable baseline PET\/CT and iPET, were retrospectively reviewed. We calculated the baseline TMTV and TLG values. All iPET responses were analyzed using the Deauville 5\u2010point scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On univariate analysis, a prognostic index for PTCL (PIT) higher than 2 (hazard ratio [HR], 2.03; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.026), high TMTV (&gt;389\u00a0cm<jats:sup>3<\/jats:sup>; HR, 2.24; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.01), high TLG (&gt;875; HR, 3.77; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.0005), and positive iPET (HR, 2.18; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.009) were significantly associated with poorer progression\u2010free survival (PFS). On multivariate analysis, only high TLG and positive iPET independently predicted both poorer overall survival (OS) and PFS. A model combining TLG and iPET showed that patients with low TLG and negative iPET had superior outcomes, with a 5\u2010year PFS and OS of 72% and 90%, respectively. Conversely, both 5\u2010year PFS and OS for those with high TLG and positive iPET were 0%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, TLG combined with iPET predicted survival in PTCL more accurately. This information may help in the development of risk\u2010adapted treatment strategies for PTCL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3226","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T14:05:08Z","timestamp":1592489108000},"page":"5509-5518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Baseline total lesion glycolysis combined with interim positron emission tomography\u2010computed tomography is a robust predictor of outcome in patients with peripheral T\u2010cell lymphoma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3218-2446","authenticated-orcid":false,"given":"Akihiro","family":"Kitadate","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Department of Internal Medicine Kameda Medical Center Kamogawa Japan"},{"name":"Department of Hematology, Nephrology, and Rheumatology Akita University Graduate School of Medicine Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6504-9046","authenticated-orcid":false,"given":"Kentaro","family":"Narita","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Internal Medicine Kameda Medical Center Kamogawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouta","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Internal Medicine Kameda Medical Center Kamogawa Japan"},{"name":"Department of Hematology Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-3346","authenticated-orcid":false,"given":"Toshiki","family":"Terao","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Internal Medicine Kameda Medical Center Kamogawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Tsushima","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Internal Medicine Kameda Medical Center Kamogawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7892-4674","authenticated-orcid":false,"given":"Hiroki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Internal Medicine Kameda Medical Center Kamogawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1021-7911","authenticated-orcid":false,"given":"Yoshiaki","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Internal Medicine Kameda Medical Center Kamogawa Japan"},{"name":"Department of Hematology Graduate School of 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