{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:23:34Z","timestamp":1768868614799,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary tumor location is an established prognostic factor in patients with (metastatic) colon cancer. Colon tumors can be divided into left\u2010sided and right\u2010sided tumors. The aim of this study was to determine the impact of primary tumor location on treatment and overall survival (OS) in patients with peritoneal metastases (PM) from colon cancer. This study is a retrospective, population\u2010based cohort study. Records of patients diagnosed with colon cancer and synchronous PM, from 1995 through 2016, were retrieved from the Netherlands Cancer Registry (NCR). Data on diagnosis, staging, and treatment were extracted from the medical records by specifically trained NCR personnel. Information on survival status was updated annually using a computerized link with the national civil registry. In total, 7930 patients were included in this study; 4555 (57.4%) had a right\u2010sided and 3375 (42.6%) had a left\u2010sided primary tumor. In multivariable analysis right\u2010sided primary tumor was associated with worse OS (HR: 1.11, 95% CI 1.03\u20101.19, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007). Of all patients diagnosed with PM, 564 (7.1%) underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS\u2010HIPEC). Patients with left\u2010sided primary tumors were more often candidates for CRS\u2010HIPEC (6.5% vs. 8.0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008). OS of patients with right\u2010 and left\u2010sided tumors who underwent CRS\u2010HIPEC did not significantly differ. In conclusion, primary right\u2010sided colon cancer was an independent prognostic factor for decreased OS in patients diagnosed with synchronous PM. In patients treated with CRS\u2010HIPEC location of the primary tumor did not influence survival.<\/jats:p>","DOI":"10.1002\/cam4.3243","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T12:48:02Z","timestamp":1593694082000},"page":"5851-5859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A population\u2010based study on the prognostic impact of primary tumor sidedness in patients with peritoneal metastases from colon cancer"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2702-1915","authenticated-orcid":false,"given":"Nadine L.","family":"de Boer","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Erasmus MC Cancer Institute Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Rovers","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Cancer Institute Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobus W.A.","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Cancer Institute Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva V. E.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Erasmus MC Cancer Institute Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra R. M.","family":"Brandt\u2010Kerkhof","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Erasmus MC Cancer Institute Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels F. M.","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Surgery Antoni van Leeuwenhoek Hospital The Netherlands Cancer Institute Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes H. W.","family":"de Wilt","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Radboud UMC Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip H.","family":"de Reuver","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Radboud UMC Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Development Netherlands Comprehensive Cancer Organisation (IKNL) Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignace H. J. T.","family":"de Hingh","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Cancer Institute Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Erasmus MC Cancer Institute Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-015-9719-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9966-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.7160"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25116"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25356"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181a45d86"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3145-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.9285"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02274.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25596"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199502000-00002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181c703a4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.07.016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.4227"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-08100-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124234"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.2.158"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10635"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju427"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx119"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.11.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2019.10.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11289"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07373-0"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07255-5"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-014-2801-y"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6264-x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002087"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1984.262"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302014"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)64794-6"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5545-0"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx175"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29129"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000171605"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605164"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26086"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.1366"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200340"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07452-2"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.3243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.3243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T21:10:21Z","timestamp":1704229821000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.3243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,2]]},"references-count":41,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/cam4.3243"],"URL":"https:\/\/doi.org\/10.1002\/cam4.3243","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,2]]},"assertion":[{"value":"2020-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}