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Thus, the peritoneal immune microenvironment is crucial for EOC progression. Previous reports indicate that the main immune cells within the peritoneum are M2 macrophages, specifically tumor\u2010associated macrophages (TAMs). The communication between TAMs and tumor cells plays an important role in EOC development, and exosomes, acting as micro\u2013message carriers, occupy an essential position in this process. Microarray analyses of exosomes revealed that miR\u2010221\u20103p was enriched in M2 exosomes. Furthermore, miR\u2010221\u20103p suppressed cyclin\u2010dependent kinase inhibitor 1B (CDKN1B) directly. Thus, miR\u2010221\u20103p contributed to the proliferation and G1\/S transition of EOC cells. Additionally, low levels of CDKN1B were associated with EOC progression and poor prognosis. These observations suggest that TAMs\u2010derived exosomal miR\u2010221\u20103p acts as a regulator of EOC progression by targeting CDKN1B. The results of this study confirm that certain exosomal microRNAs may provide novel diagnostic biomarkers and therapeutic targets for EOC.<\/jats:p>","DOI":"10.1002\/cam4.3252","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T09:58:39Z","timestamp":1593251919000},"page":"5976-5988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Exosomes released from M2 macrophages transfer miR\u2010221\u20103p contributed to EOC progression through targeting CDKN1B"],"prefix":"10.1002","volume":"9","author":[{"given":"Xiaoduan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynecology Shanghai First Maternity and Infant Hospital Tongji University School of Medicine  Shanghai 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