{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:01Z","timestamp":1772118121707,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Referrals for Lynch syndrome (LS) assessment have traditionally been based on personal and family medical history. The introduction of universal screening practices has allowed for referrals based on immunohistochemistry tests for mismatch repair (MMR) protein expression. This study aims to characterize the effect of universal screening in a publicly funded healthcare system with comparison to patients referred by traditional criteria, from January 2012 to March 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patient files from the time of initiation of universal screening from 2012 to 2017 were reviewed. Patients were sorted into two groups: (a) universally screened and (b) referred by traditional methods. Mutation detection rates, analysis of traditional testing criteria met, and cascade carrier testing were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mutation detection rate of the universal screening group was higher than the traditionally referred group (45\/228 (19.7%) vs 50\/390 (12.5%),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.05), though each were able to identify unique patients. An analysis of testing criteria met by each patient showed that half of referred patients from the universal screening group could not meet any traditional testing criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The implementation of universal screening in a publicly funded system will increase efficiency in detecting patients with LS. The resources available for genetic testing and counseling may be more limited in public systems, thus inclusion of secondary screening with\n                      <jats:italic>BRAF<\/jats:italic>\n                      and\n                      <jats:italic>MLH1<\/jats:italic>\n                      promoter hypermethylation testing is key to further optimizing efficiency.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.3279","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T03:48:06Z","timestamp":1595476086000},"page":"6507-6514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating the impact of universal Lynch syndrome screening in a publicly funded healthcare system"],"prefix":"10.1002","volume":"9","author":[{"given":"Petra W. C.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biology University of the Fraser Valley Abbotsford BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-5560","authenticated-orcid":false,"given":"Angela C.","family":"Bedard","sequence":"additional","affiliation":[{"name":"BC Cancer Hereditary Cancer Program Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setareh","family":"Samimi","sequence":"additional","affiliation":[{"name":"Hematologie et Oncologie Departement H\u00f4pital du Sacr\u00e9\u2010Coeur de Montr\u00e9al Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivienne K.","family":"Beard","sequence":"additional","affiliation":[{"name":"Department of Biology University of the Fraser Valley Abbotsford BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Hong","sequence":"additional","affiliation":[{"name":"BC Cancer Hereditary Cancer Program Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E. 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