{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:31:05Z","timestamp":1754109065876,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006636","name":"Swedish Research Council for Health, Working Life and Welfare","doi-asserted-by":"crossref","award":["[2016-07282]"],"award-info":[{"award-number":["[2016-07282]"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Some studies hypothesize that birth month\u2014as a proxy of exposure to ultraviolet radiation in early infancy\u2014is associated with increased risk of skin tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied a national cohort of all 5\u00a0874\u00a0607 individuals born in Sweden to parents of Swedish or Nordic origin as a proxy for Caucasian origin, 1950 to 2014. The cohort was followed for incident skin tumors, including squamous cell carcinomas and melanomas but not basal cell carcinomas, through 2015 from birth up to age 65 for the oldest cohort. Cox regression estimated the association between month of birth and risk of skin tumors in models adjusted for sex, calendar period, and education. Crude observed to expected ratios were also calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 33\u00a0914 cases of skin tumors, of these, 3025 were squamous cell cancer, 16\u00a0968 malignant melanoma and 8493 melanoma in situ\/other and 5\u00a0428 squamous cell in situ\/other in 192\u00a0840\u00a0593 person\u2010years of follow\u2010up. Observed to expected ratios by month of birth showed no association between month of birth and risk of skin tumors, and the same result was seen when Cox regression analysis was used. Subgroup analyses by sex, educational level, calendar period, or age at follow\u2010up similarly showed no association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This large register\u2010based cohort study showed no evidence of a higher risk of skin tumors in those born during the spring. Thus, this study lends no support to the hypothesis that birth during spring is a major risk factor for later skin tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3286","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T16:54:58Z","timestamp":1594054498000},"page":"6062-6068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Birth month and risk of skin tumors\u2014Follow up of six million Caucasians born from 1950 to 2014 in Sweden"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-4530","authenticated-orcid":false,"given":"Rickard","family":"Ljung","sequence":"first","affiliation":[{"name":"Unit of Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Talb\u00e4ck","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal R.","family":"Khanolkar","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"},{"name":"GOS Institute of Child Health University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Feychting","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008980919928"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.10.016"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3502"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04070.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00791.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt277"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.522"},{"key":"e_1_2_11_9_1","first-page":"788","article-title":"The effect of exposure to ultraviolet radiation in infancy on melanoma risk","volume":"228","author":"Gefeller O","year":"2016","journal-title":"Stud Health Technol Inform"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx059"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx024"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx026"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-016-0117-y"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802247664"},{"key":"e_1_2_11_15_1","unstructured":"National Cancer Institute.Surveillance Epidemiology and End Results program (SEER). Cancer Stat Facts: Melanoma of the Skin. New cases and deaths: Rate of New Cases per 100 000 Persons by Race\/Ethnicity & Sex: Melanoma of the Skin.https:\/\/seer.cancer.gov\/statfacts\/html\/melan.html(Accessed 29th June 2020)."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30502"},{"key":"e_1_2_11_17_1","unstructured":"Swedish Radiation Safety Authority.Special sun recommendations for children. Retrieved fromhttp:\/\/www.stralsakerhetsmyndigheten.se\/In\u2010English\/About\u2010the\u2010Swedish\u2010Radiation\u2010Safety\u2010Authority1\/Enjoy\u2010the\u2010sun\u2010safely\/Special\u2010sun\u2010recommendations\u2010for\u2010children\/"},{"issue":"8","key":"e_1_2_11_18_1","first-page":"1222","article-title":"Intentional sun exposure in infancy in Sakarya, Turkey","volume":"27","author":"Cinar ND","year":"2006","journal-title":"Saudi Med J"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.2002.tb00901.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wombi.2013.03.002"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.3286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.3286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T21:09:59Z","timestamp":1704229799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.3286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"references-count":19,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/cam4.3286"],"URL":"https:\/\/doi.org\/10.1002\/cam4.3286","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2020,7,6]]},"assertion":[{"value":"2019-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}