{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:07:59Z","timestamp":1790402879953,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We explored the potential overall survival (OS) benefit of bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), procarbazine, and prednisone (BEACOPP) over doxorubicin (Adriamycin), bleomycin, vinblastine, and dacarbazine (ABVD) in a pooled analysis of four randomized trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Primary objective was to evaluate the OS impact of BEACOPP using individual patient data. Secondary objectives were progression\u2010free survival (PFS), secondary cancers, and use of autologous stem cell transplantation (ASCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 1227 patients were included. The 7\u2010year OS was 84.3% (95% CI 80.8\u201087.2) for ABVD vs 87.7% (95% CI 84.5\u201090.2) for BEACOPP. Two follow\u2010up periods were identified based on survival curves and hazard ratio (HR) over time. For the first 18\u00a0months, there was no difference. For the second period of \u226518\u00a0months, ABVD patients had a higher death risk (HR<jats:sub>ABVD\u00a0vs\u00a0BEACOPP<\/jats:sub>\u00a0=\u00a01.59; 95% CI 1.09\u20102.33). A Cox model stratified by trial and evaluating the effect of treatment and International Prognostic Index (IPI) score as fixed effects showed that both were statistically significant (treatment, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0185; IPI score, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0107). The 7\u2010year PFS was 71.1% (95% CI 67.1\u201074.6) for ABVD vs 81.1% (95% CI 77.5\u201084.2) for BEACOPP (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). After ABVD, 25 secondary cancers (4.0%) were reported with no myelodysplasia (MDS)\/acute myeloid leukemia (AML) compared to 36 (6.5%) after BEACOPP, which included 13 patients with MDS\/AML. Following ABVD, 86 patients (13.8%) received ASCT vs 39 (6.4%) for BEACOPP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This analysis showed a slight improvement in OS for BEACOPP and confirmed a PFS benefit. Frontline use of BEACOPP instead of ABVD increased secondary leukemia incidence but halved the requirement for ASCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3298","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T08:42:17Z","timestamp":1595666537000},"page":"6565-6575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Long\u2010term overall survival and toxicities of ABVD vs BEACOPP in advanced Hodgkin lymphoma: A pooled analysis of four randomized trials"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-810X","authenticated-orcid":false,"given":"Marc P. E.","family":"Andr\u00e9","sequence":"first","affiliation":[{"name":"Hematology Department CHU UCL Namur Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Carde","sequence":"additional","affiliation":[{"name":"Institut Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Viviani","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy"},{"name":"Division of Hemato\u2010Oncology IEO European Institute of Oncology Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Bellei","sequence":"additional","affiliation":[{"name":"Fondazione Italiana Limfomi Dipartimento di Scienze Medische e Chirurgiche Materno\u2010Infantili e dell'Adulto University of Modena, e Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fortpied","sequence":"additional","affiliation":[{"name":"European Organisation for Research and Treatment of Cancer Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Department of Hematology, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro M.","family":"Gianni","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy"},{"name":"Division of Hemato\u2010Oncology IEO European Institute of Oncology Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Brice","sequence":"additional","affiliation":[{"name":"APHP Hopital Saint\u2010louis Hemato\u2010oncologie Universit\u00e9 Paris Diderot Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Casasnovas","sequence":"additional","affiliation":[{"name":"Hematology department and INSERM1231 H\u00f4pital F. Mitterand Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo G.","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Fondazione IRCCS Policlinico San Matteo and Universit\u00e0 degli Studi di Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-2651","authenticated-orcid":false,"given":"Pier Luigi","family":"Zinzani","sequence":"additional","affiliation":[{"name":"Institute of Hematology \u201cSer\u00e0gnoli\u201d University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehan","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Unit\u00e9 H\u00e9mopathies Lympho\u00efdes AP\u2010HP H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Iannitto","sequence":"additional","affiliation":[{"name":"Department of Oncology Haematology Unit AOU Policlinico P. Giaccone Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Hematology Universit\u00e0 degli Studi di Milano e Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette","family":"Bri\u00e8re","sequence":"additional","affiliation":[{"name":"APHP Hopital Saint\u2010louis Hemato\u2010oncologie Universit\u00e9 Paris Diderot Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurianne","family":"Cl\u00e9ment\u2010Filliatre","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Heczko","sequence":"additional","affiliation":[{"name":"Department of Hematology Besancon Hospital Besancon 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