{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:41:29Z","timestamp":1784641289685,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","award":["20164Y0254"],"award-info":[{"award-number":["20164Y0254"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Development Foundation","doi-asserted-by":"publisher","award":["19MC1911000"],"award-info":[{"award-number":["19MC1911000"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Compared with Occident's data, the incidence of Human papillomavirus (HPV)\u2010driven oropharyngeal squamous cell carcinomas (OPSCCs) had been reported as relatively low in Mainland China. The objective of this study was to report the integrated prevalence of HPV and Epstein\u2010Barr virus (EBV), and further evaluate the different behaviors of HPV\u2010positive and \u2010negative OPSCCs in eastern China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cohort of 170 nonmetastatic OPSCCs treated from January 2007 to July 2019, p16 protein expression, HPV genotypes, and Epstein\u2010Barr virus\u2010encoded RNA (EBER) were determined by immunohistochemistry (IHC) and in situ hybridization (ISH). The clinical and pathologic findings were further collected and analyzed to comprehensively reveal the behaviors of Chinese OPSCCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 170 tumor tissues evaluated, 57.6% (98) samples had positive p16 expressions. A total of 65.1% (99\/152) samples had positive HPV genotypes, besides HPV16 (92\/152), HPV11, 18, 33, 53, and 58 were also detected. The positive rate of EBER was 7.2% (9\/124), and the co\u2010infection rate of EBV\/HPV was 4.0%. Related to the unequal distributions of p16 expression, HPV\u2010related tumors arisen from tonsillar and non\u2010tonsillar accounted for 68.8% (75\/109) and 37.7% (23\/61) of their cases, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). With a median follow\u2010up time of 13.1\u00a0months, significant survival advantages of HPV\u2010related OSPCC were observed; 1\u2010year OS, PFS, RFS, and MFS were 83.2% vs 96.7% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), 71.6% vs 96.2% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), 77.7% vs 96.2% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002), and 90.4% vs 100.0% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.024) in p16\u2010negative and \u2010positive cases, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The relative percent of HPV\u2010positive OPSCCs in this study is close to the positive rate in many Western countries and a strong predilection was discovered for the tonsillar. The EBV infection and co\u2010infection of HPV\/EBV were largely low. The prognosis of HPV\u2010positive OSPCCs was more favorable than its negative counterpart.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3339","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T20:03:34Z","timestamp":1595880214000},"page":"6556-6564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5920-808X","authenticated-orcid":false,"given":"Tingting","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaosu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"},{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"},{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Hua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"},{"name":"Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengtao","family":"Su","sequence":"additional","affiliation":[{"name":"Cancer Institute Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"},{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-3312","authenticated-orcid":false,"given":"Xueguan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.5970"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.3870"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2019.05.017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24336"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164491"},{"issue":"2018","key":"e_1_2_9_9_1","first-page":"9594568","article-title":"Association of p16 as prognostic factors for oropharyngeal cancer: evaluation of p16 in 1470 patients for a 16 year study in Northeast China","volume":"17","author":"Meng 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Head and neck cancers. Version 1.2020. 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