{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:26:46Z","timestamp":1792506406588,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030312003"],"award-info":[{"award-number":["2017A030312003"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572962"],"award-info":[{"award-number":["81572962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the prognostic value of magnetic resonance imaging (MRI)\u2010determined cervical lymph node (CLN) size in nasopharyngeal carcinoma (NPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 2066 patients with NPC treated with intensity\u2010modulated radiotherapy, and randomly divided them into two groups, in a 1:1 ratio. One group was used for training (the training group), and the other one was for internal validation (the validation group). All patients had undergone MRI examination and the maximal axial diameters (MAD) of the axial plane of all positive nodes had been measured and recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 683 patients with CLN metastases in the training group (n\u00a0=\u00a01033), MAD\u00a0=\u00a04\u00a0cm was associated with worse OS (64.7% vs 84.6%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), DFS (55.9% vs 76.3%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001), and DMFS (67.6% vs 86.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001). Multivariate analysis showed that MAD\u00a0=\u00a04\u00a0cm was a significant negative prognostic factor for OS (HR\u00a0=\u00a02.058;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.025), DFS (HR\u00a0=\u00a01.727;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.049), and DMFS (HR\u00a0=\u00a02.034;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.036). When MRI\u2010determined MAD\u00a0=\u00a04\u00a0cm was classified as N3 in the N classification, the OS, DFS, DMFS, and RRFS survival curves were well separated. The OS, DFS, DMFS, and RRFS concordance indexes were not statistically different between the proposed N staging system and the UICC\/AJCC staging system in the training group, or between the training group and the validation group (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MAD\u00a0=\u00a04\u00a0cm on axial MRI slices can be recommended as a prognostic factor in future versions of the UICC\/AJCC NPC staging system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.3392","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T08:29:16Z","timestamp":1597393756000},"page":"7100-7106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prognostic value of MRI\u2010determined cervical lymph node size in nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"9","author":[{"given":"Cheng\u2010Long","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1683-0837","authenticated-orcid":false,"given":"Rui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Ping","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tian","sequence":"additional","affiliation":[{"name":"Imaging Diagnosis and Interventional Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center Guangzhou 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