{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T04:30:57Z","timestamp":1771907457097,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal malignancies (SNM) include malignant neoplasms of various histologies that originate from the paranasal sinuses or nasal cavity. This study reported the safety and efficacy of particle\u2010beam radiation therapy (PBRT) for the treatment of sinonasal malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>One\u2010hundred\u2010and\u2010eleven patients with nonmetastatic sinonasal malignancies received definitive (82.9%) or salvage (31.5%) PBRT. The majority (85.6%) of patients presented with T3\/4 disease, and only 19 (17.1%) had R0 or R1 resection. Seventy (63.1%) patients received carbon\u2010ion radiotherapy (CIRT), 37 received proton radiotherapy (PRT) followed by CIRT boost, and 4 received PRT alone. Prognostic factors were analyzed using Cox regression for univariate and multiple regression. Toxicities were reported using the Common Terminology Criteria for Adverse Events (version 4.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up was 20.2\u00a0months for the entire cohort. The 2\u2010year local progression\u2010free survival (LPFS), regional progression\u2010free survival (RPFS), distant metastasis\u2010free survival (DMFS), progression\u2010free survival (PFS), and overall survival (OS) rates were 83%, 97.2%, 85.9%, 66%, and 82%, respectively. Re\u2010irradiation and large GTV were the significant factors for OS. Melanoma and sarcoma patients had significantly higher distant metastatic rate, and poorer OS and PFS. Late toxicity occurred in 22 (19.8%) patients, but only 4 (3.6%) patients experienced grades 3\u20104 late toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Particle\u2010beam radiation therapy results in excellent local\u2010regional control with extremely low serve toxicities for patients with SNM. Sarcoma and melanoma were featured with a greater risk of death from distant dissemination. Patients who underwent re\u2010irradiation had significantly worse OS. PBRT is feasible and safe in the management of SNM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3393","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T21:51:34Z","timestamp":1601070694000},"page":"7914-7924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Particle beam radiation therapy for sinonasal malignancies: Single institutional experience at the Shanghai Proton and Heavy Ion Center"],"prefix":"10.1002","volume":"9","author":[{"given":"Weixu","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Shanghai Proton and Heavy Ion Center Shanghai China"},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Shanghai Proton and 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