{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:14:20Z","timestamp":1781525660364,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG2013"],"award-info":[{"award-number":["IG2013"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The neutrophil to lymphocyte ratio (NLR) and the lymphocyte to monocyte ratio (LMR) can reflect both the myeloid dysfunction and T\u2010cell immune suppression and have prognostic significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 771 newly diagnosed advanced\u2010stage Hodgkin Lymphoma (HL) patients we evaluated the baseline values of NLR and LMR as predictors of clinical outcome. According to the multicenter prospective phase II GITIL\u2010HD0607 trial, all patients received two ABVD courses and if PET\u20102 negative received four additional ABVD cycles while if PET\u20102\u2010positive patients were randomized to either BEACOPP escalated (Be) plus BEACOPP baseline (Bb) (4\u00a0+\u00a04 courses) or Be\u00a0+\u00a0Bb (4\u00a0+\u00a04) and Rituximab. PET scans were centrally reviewed by an expert panel by Blinded Independent Central Review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher NLR and lower LMR were associated with a PET\u20102 positivity and failure to achieve long\u2010term disease control, respectively. By univariate and multivariate analysis, large nodal mass (&gt;7\u00a0cm), IPS\u00a0\u2265\u00a03, NLR\u00a0&gt;\u00a06 were strong independent predictors of early PET\u20102 response after ABVD. Only NLR\u00a0&gt;\u00a06 and IPS\u00a0\u2265\u00a03 were strong independent predictors of outcome at diagnosis; however, when PET\u20102 status was added, only PET\u20102\u2010positive status and IPS\u00a0\u2265\u00a03 were independent predictors of PFS. Focusing on PET\u20102\u2010negative patients, those with NLR\u00a0&gt;\u00a06 had an inferior 3\u2010year PFS compared to patients with NLR\u00a0\u2264\u00a06 (84% vs 89% months, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In advanced\u2010stage HL patients treated with a PET\u20102\u2010driven strategy, IPS\u00a0\u2265\u00a03 and NLR\u00a0&gt;\u00a06 are independent predictors of outcome at diagnosis while the presence of large nodal mass, IPS\u00a0\u2265\u00a03, and NLR\u00a0&gt;\u00a06 at diagnosis are independent predictors of early ABVD response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3396","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T14:02:53Z","timestamp":1604671373000},"page":"8735-8746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The neutrophil to lymphocyte ratio (NLR) and the presence of large nodal mass are independent predictors of early response: A subanalysis of the prospective phase II PET\u20102\u2010adapted HD0607 trial"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-4433","authenticated-orcid":false,"given":"Alessandra","family":"Romano","sequence":"first","affiliation":[{"name":"Dipartimento di Specialit\u00e0 medico\u2010Chirurgiche, CHIRMED Sezione di Ematologia Universit\u00e0 degli studi di Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pavoni","sequence":"additional","affiliation":[{"name":"Ematologia Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Di Raimondo","sequence":"additional","affiliation":[{"name":"Dipartimento di Specialit\u00e0 medico\u2010Chirurgiche, CHIRMED Sezione di Ematologia Universit\u00e0 degli studi di Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tarella","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology Unit Istituto Europeo di Oncologia Milan Italy"},{"name":"Universit\u00e0 degli Studi di Milano Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Viviani","sequence":"additional","affiliation":[{"name":"Ematologia e onco\u2010ematologia pediatrica Fondazione IRCSS Istituto Nazionale dei Tumori Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[{"name":"Ematologia Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Patti","sequence":"additional","affiliation":[{"name":"Ematologia Azienda Villa Sofia\u2010Cervello Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Picardi","sequence":"additional","affiliation":[{"name":"Ematologia Universit\u00e0 Federico II Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cantonetti","sequence":"additional","affiliation":[{"name":"Oncoematologia Policlinico Tor Vergata Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"La Nasa","sequence":"additional","affiliation":[{"name":"Ematologia Ospedale R.Binaghi Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Trentin","sequence":"additional","affiliation":[{"name":"Ematologia Dipartimento di Medicina Universit\u00e0 di Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bolis","sequence":"additional","affiliation":[{"name":"Ematologia Ospedale San Gerardo Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Zoli","sequence":"additional","affiliation":[{"name":"Ematologia Ospedale S. 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