{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:49:36Z","timestamp":1720658976494},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T00:00:00Z","timestamp":1348617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lymphoma, not otherwise specified (<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> NOS<\/jats:styled-content>) with genomic aberrations has been shown to resemble lymphoma\u2010type adult <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell leukemia\/lymphoma (<jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content>) in terms of its genomic aberration patterns, histopathology, and prognosis. We have shown recently that a majority of patients with acute\u2010type <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> have multiple subclones that were likely produced in lymph nodes. In this study, we analyzed whether <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> NOS<\/jats:styled-content> with genomic aberrations also has multiple subclones as found in <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> by means of high\u2010resolution oligo\u2010array comparative genomic hybridization (<jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content>). Thirteen cases of <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> NOS<\/jats:styled-content> were available for 44K high\u2010resolution array <jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content> analysis. The results showed that 11 (84.6%) of the 13 cases had a log2 ratio imbalance, suggesting that multiple subclones exist in <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> NOS<\/jats:styled-content> with genomic aberrations. In order to analyze the association between multiple subclones and prognosis, we used previous <jats:styled-content style=\"fixed-case\">bacterial\u2010artificial chromosome<\/jats:styled-content> (BAC) array analyses for 29 cases and found that the existence of multiple subclones was associated with a poor prognosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0279).<\/jats:p>","DOI":"10.1002\/cam4.34","type":"journal-article","created":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T13:36:38Z","timestamp":1348666598000},"page":"289-294","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of multiple subclones in peripheral <scp>T<\/scp>\u2010cell lymphoma, not otherwise specified with genomic aberrations"],"prefix":"10.1002","volume":"1","author":[{"given":"Noriaki","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Chikusa\u2010ku Kanokoden 1\u20101 Nagoya 464\u20108681 Japan"},{"name":"Department of Cancer Genetics Nagoya University Graduate School of Medicine Showa\u2010ku Tsurumai 65 Nagoya 466\u20108550 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Umino","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Chikusa\u2010ku Kanokoden 1\u20101 Nagoya 464\u20108681 Japan"},{"name":"Hematology and Oncology Mie University Graduate School of Medicine Edobashi 2\u2010174 Tsu Mie 514\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Chikusa\u2010ku Kanokoden 1\u20101 Nagoya 464\u20108681 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Arita","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Chikusa\u2010ku Kanokoden 1\u20101 Nagoya 464\u20108681 Japan"},{"name":"Third Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Sugitani 2630 Toyama 930\u20100194 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennosuke","family":"Karube","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Chikusa\u2010ku Kanokoden 1\u20101 Nagoya 464\u20108681 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Chikusa\u2010ku Kanokoden 1\u20101 Nagoya 464\u20108681 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University Asahimachi 67 Kurume Fukuoka 830\u20100011 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Seto","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Chikusa\u2010ku Kanokoden 1\u20101 Nagoya 464\u20108681 Japan"},{"name":"Department of Cancer Genetics Nagoya University Graduate School of Medicine Showa\u2010ku Tsurumai 65 Nagoya 466\u20108550 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"306","volume-title":"World Health Organization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues","author":"Pileri S. 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