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By binding to PD\u2010L1 (programmed cell death\u2010ligand 1), it blocks TCR and its costimulus signal transduction, inhibits the activation and proliferation of T cells, depletes the function of effector T cells, and enables tumor cells to achieve immune escape. In recent years, immunocheckpoint blocking therapy targeting the PD\u20101\/PD\u2010L1 axis has achieved good results in a variety of malignant tumors, pushing tumor immunotherapy to a new milestone, such as anti\u2010PD\u20101 monoclonal antibody Nivolumab, Pembrolizumab, and anti\u2010PD\u2010L1 monoclonal antibody Atezolizumab, which are considered as potential antitumor drugs. It was found in clinical use that some patients obtained long\u2010term efficacy, but most of them developed drug resistance recurrence in the later stage. The high incidence of drug resistance (including primary and acquired drug resistance) still cannot be ignored, which limited its clinical application and became a new problem in this field. Due to tumor heterogeneity, current limited research shows that PD\u20101 or PD\u2010L1 monoclonal antibody drug resistance may be related to the following factors: mutation of tumor antigen and antigen presentation process, multiple immune checkpoint interactions, immune microenvironment changes dynamically, activation of oncogenic pathways, gene mutation and epigenetic changes of key proteins in tumors, tumor competitive metabolism, and accumulation of metabolites, etc, mechanisms of resistance are complex. Therefore, it is the most urgent task to further elucidate the mechanism of immune checkpoint inhibitor resistance, discover multitumor universal biomarkers, and develop new target agents to improve the response rate of immunotherapy in patients. In this study, the mechanism of anti\u2010PD\u20101\/PD\u2010L1 drug resistance in tumors, the potential biomarkers for predicting PD\u20101 acquired resistance, and the recent development of combination therapy were reviewed one by one. It is believed that, based on the complex mechanism of drug resistance, it is of no clinical significance to simply search for and regulate drug resistance targets, and it may even produce drug resistance again soon. It is speculated that according to the possible tumor characteristics, three types of treatment methods should be combined to change the tumor microenvironment ecology and eliminate various heterogeneous tumor subsets, so as to reduce tumor drug resistance and improve long\u2010term clinical efficacy.<\/jats:p>","DOI":"10.1002\/cam4.3410","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T05:57:37Z","timestamp":1599026257000},"page":"8086-8121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":184,"title":["Study and analysis of antitumor resistance mechanism of PD1\/PD\u2010L1 immune checkpoint blocker"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6617-1713","authenticated-orcid":false,"given":"Zhengyi","family":"Wang","sequence":"first","affiliation":[{"name":"GCP Center of Sichuan Academy of Medical Sciences and Sichuan Provincial People\u2019s Hospital 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