{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:28:40Z","timestamp":1782793720535,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["107592"],"award-info":[{"award-number":["107592"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["110515"],"award-info":[{"award-number":["110515"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical resection is considered to be of purely diagnostic value in aggressive lymphoma. Evidence for an impact on outcome is scant and restricted to retrospective observations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the \u201cPositron Emission Tomography\u2010guided Therapy of Aggressive non\u2010Hodgkin Lymphomas\u201d (PETAL) trial, patients with a negative baseline positron emission tomography (PET) scan were documented in a prospective observational substudy. Baseline PET\u2010negative patients with the absence of lymph node enlargement on computed tomography and a negative bone marrow biopsy were considered to have undergone complete lymphoma resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010two of 1,041 patients (7.9%) had a negative baseline PET scan, and 67 were included in this analysis. All were treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), plus rituximab for CD20\u2010positive lymphomas. Among 52 patients with diffuse large B\u2010cell lymphoma (DLBCL), 48 had completely resected disease. Their outcome tended to be better than that of 115 baseline PET\u2010positive stage I DLBCL patients treated in the main part of the PETAL trial (2\u2010year progression\u2010free survival 92.7% [95% confidence interval 84.7\u2010100] versus 88.4% [82.5\u201094.3], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.056; 2\u2010year overall survival 92.7% [84.7\u2010100] versus 93.7% [89.2\u201098.2], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.176), but this was restricted to patients below the age of 60\u00a0years (2\u2010year progression\u2010free survival 100% versus 92.2% [84.8\u201099.6], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.031; 2\u2010year overall survival 100% versus 95.9% [90.2\u2010100], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.075). In peripheral T\u2010cell lymphoma, eight of 11 patients had completely resected disease. In contrast to DLBCL, complete resection was not associated with improved outcome compared to the control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Young patients with early stage DLBCL may benefit from complete lymphoma resection prior to immunochemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3448","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T07:54:09Z","timestamp":1600242849000},"page":"8386-8396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of complete surgical resection on outcome in aggressive non\u2010Hodgkin lymphoma treated with immunochemotherapy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2766-1696","authenticated-orcid":false,"given":"Christine","family":"Schmitz","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr H\u00e4matologie Universit\u00e4tsklinikum Essen 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