{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T20:41:27Z","timestamp":1774039287670,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T00:00:00Z","timestamp":1417996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many patients with stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> colon cancer will die of their disease despite curative surgery. Therefore, identification of patients at high risk of poor outcome after surgery for stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> colon cancer is desirable. This study aims to validate a clinical risk score to predict cancer\u2010specific survival in patients undergoing surgery for stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> colon cancer. Patients undergoing surgery for stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> colon cancer in 16 hospitals in the West of Scotland between 2001 and 2004 were identified from a prospectively maintained regional clinical audit database. Overall and cancer\u2010specific survival rates up to 5\u00a0years were calculated. A total of 871 patients were included. At 5\u00a0years, cancer\u2010specific survival was 81.9% and overall survival was 65.6%. On multivariate analysis, age \u226575\u00a0years (hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) 2.11, 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.57\u20132.85; <jats:italic>P<\/jats:italic>&lt;0.001) and emergency presentation (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.97, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.43\u20132.70; <jats:italic>P<\/jats:italic>&lt;0.001) were independently associated with cancer\u2010specific survival. Age and mode of presentation <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s were added to form a clinical risk score of 0\u20132. The cancer\u2010specific survival at 5\u00a0years for patients with a cumulative score 0 was 88.7%, 1 was 78.2% and 2 was 65.9%. These results validate a modified simple clinical risk score for patients undergoing surgery for stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> colon cancer. The combination of these two universally documented clinical factors provides a solid foundation for the examination of the impact of additional clinicopathological and treatment factors on overall and cancer\u2010specific survival.<\/jats:p>","DOI":"10.1002\/cam4.352","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T02:45:38Z","timestamp":1418093138000},"page":"84-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Validation of a modified clinical risk score to predict cancer\u2010specific survival for stage <scp>II<\/scp> colon cancer"],"prefix":"10.1002","volume":"4","author":[{"given":"Raymond","family":"Oliphant","sequence":"first","affiliation":[{"name":"University Department of Surgery Faculty of Medicine University of Glasgow Glasgow Royal Infirmary Glasgow G4 0SF U.K"},{"name":"West of Scotland Cancer Surveillance Unit Institute of Health and Wellbeing University of Glasgow Glasgow G12 8RZ U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G.","family":"Horgan","sequence":"additional","affiliation":[{"name":"University Department of Surgery Faculty of Medicine University of Glasgow Glasgow Royal Infirmary Glasgow G4 0SF U.K"},{"name":"West of Scotland Colorectal Cancer Managed Clinical Network Glasgow Royal Infirmary Glasgow G4 0SF U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Morrison","sequence":"additional","affiliation":[{"name":"West of Scotland Cancer Surveillance Unit Institute of Health and Wellbeing University of Glasgow Glasgow G12 8RZ U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald C.","family":"McMillan","sequence":"additional","affiliation":[{"name":"University Department of Surgery Faculty of Medicine University of Glasgow Glasgow Royal Infirmary Glasgow G4 0SF U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"In 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