{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:17:41Z","timestamp":1787728661452,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006293","name":"American Society of Clinical Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006293","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010CA211875"],"award-info":[{"award-number":["R01\u2010CA211875"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03CA223709"],"award-info":[{"award-number":["R03CA223709"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Germ cell tumors (GCTs) are cured with therapy based on cisplatin, although a clinically significant number of patients are refractory and die of progressive disease. Based on preclinical studies indicating that refractory testicular GCTs are hypersensitive to hypomethylating agents (HMAs), we conducted a phase I trial combining the next\u2010generation HMA guadecitabine (SGI\u2010110) with cisplatin in recurrent, cisplatin\u2010resistant GCT patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with metastatic GCTs were treated for five consecutive days with guadecitabine followed by cisplatin on day 8, for a 28\u2010day cycle for up to six cycles. The primary endpoint was safety and toxicity including dose\u2010limiting toxicity (DLT) and maximum tolerated dose (MTD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The number of patients enrolled was 14. The majority of patients were heavily pretreated. MTD was determined to be 30\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      guadecitabine followed by 100\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      cisplatin. The major DLTs were neutropenia and thrombocytopenia. Three patients had partial responses by RECIST criteria, two of these patients, including one with primary mediastinal disease, completed the study and qualified as complete responses by serum tumor marker criteria with sustained remissions of 5 and 13\u00a0months and survival of 16 and 26\u00a0months, respectively. The overall response rate was 23%. Three patients also had stable disease indicating a clinical benefit rate of 46%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combination of guadecitabine and cisplatin was tolerable and demonstrated activity in patients with platinum refractory germ cell cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.3583","type":"journal-article","created":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T23:52:27Z","timestamp":1604274747000},"page":"156-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A phase 1 study of combined guadecitabine and cisplatin in platinum refractory germ cell cancer"],"prefix":"10.1002","volume":"10","author":[{"given":"Costantine","family":"Albany","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Indiana University Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan","family":"Fazal","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences and the Cancer Center at Illinois University of Illinois at Urbana\u2010Champaign Urbana IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3226-3847","authenticated-orcid":false,"given":"Ratnakar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences and the Cancer Center at Illinois University of Illinois at Urbana\u2010Champaign Urbana IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bikorimana","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences and the Cancer Center at Illinois University of Illinois at Urbana\u2010Champaign Urbana IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-8329","authenticated-orcid":false,"given":"Nabil","family":"Adra","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Indiana University Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser H.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Indiana University Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence H.","family":"Einhorn","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Indiana University Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of Medicine 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