{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:00:37Z","timestamp":1781586037840,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the feasibility of the clinical application of non\u2010invasive transthoracic echocardiography for diagnosis of pulmonary arterial hypertension induced by dasatinib (D\u2010PAH) in chronic myeloid leukemia (CML).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 451 CML patients who were examined by 2D\u2010echocardiography at least once at baseline and\/or during dasatinib therapy as frontline (<jats:italic>n<\/jats:italic>\u00a0=\u00a0196) and subsequent line (<jats:italic>n<\/jats:italic>\u00a0=\u00a0255) therapies were included in this study. D\u2010PAH was defined as right ventricular systolic pressure (RVSP) &gt;40\u00a0mm\u00a0Hg with relevant symptoms and the absence of other specific etiologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 847 echocardiographies were performed including at baseline (<jats:italic>n<\/jats:italic>\u00a0=\u00a0255) and during dasatinib treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a0592). During the median of 36.2 (0.1\u2013181.8) months of dasatinib therapy, the level of RVSP gradually increased (Spearman's <jats:italic>r<\/jats:italic>\u00a0=\u00a00.2819, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and the mean RVSP was significantly increased after taking dasatinib therapy compared with baseline. During dasatinib therapy, 56 (12.4%) patients had RVSP &gt;40\u00a0mm\u00a0Hg without (asymptomatic, <jats:italic>n<\/jats:italic>\u00a0=\u00a027, 48.2%) or with symptoms (D\u2010PAH, <jats:italic>n<\/jats:italic>\u00a0=\u00a029, 51.8%). All asymptomatic patients maintained dasatinib therapy without further symptoms and the D\u2010PAH patients ultimately switched to other tyrosine kinase inhibitors. After dasatinib discontinuation, 13 (45%) and 15 (52%) patients showed RVSP normalization and gradual decrease, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our large cohort study demonstrated that the gradual increment of RVSP might be induced by dasatinib and non\u2010invasive echocardiography can be fast way for early diagnosis as well as for monitoring of D\u2010PAH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3588","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T17:37:54Z","timestamp":1613669874000},"page":"1515-1524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Change of right ventricular systolic pressure can indicate dasatinib\u2010induced pulmonary arterial hypertension in chronic myeloid leukemia"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-2050","authenticated-orcid":false,"given":"Sung\u2010Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Hematology Catholic Hematology Hospital College of Medicine The Catholic University of Korea Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee","family":"Hyun Kong","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine Wonju Christian Hospital Yonsei University College of Medicine Wonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Leukemia Research Institute The Catholic University of Korea Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Jung","family":"Jang","sequence":"additional","affiliation":[{"name":"Leukemia Research 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