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Here, four HI patterns after CP resection based on endoscopic observation were introduced. A total of 131 CP cases treated with endoscopic endonasal approach (EEA) were reviewed retrospectively and divided into four HI patterns: no\u2010HI, mild\u2010HI, unilateral\u2010HI and bilateral\u2010HI, according to intraoperative findings. The outcomes were evaluated and compared between groups in terms of weight gain, endocrine status, electrolyte disturbance and neuropsychological function before and after surgery. A systematic correlation was found between CP origin and subsequent HI patterns. The majority of intrasellar and suprasellar stalk origins lead to a no\u2010HI pattern, the central\u2010type CP mainly develops a mild or bilateral HI pattern, and the majority of tumors with hypothalamic stalk origins result in unilateral HI and sometimes bilateral HI patterns. The proportion of tumors with a maximum diameter &gt;3\u00a0cm in the no\u2010HI group was higher than that in the mild\u2010HI group, BMI and quality of life in the no\u2010HI group showed better results than those in the other groups. The incidence of new\u2010onset diabetes insipidus in the bilateral\u2010HI group was significantly higher than that in the other groups. Memory difficulty was observed mainly in the unilateral\u2010HI and bilateral\u2010HI groups. However, the outcomes of electrolyte disturbance, sleep, and cognitive disorder in the unilateral\u2010HI group were significantly better than those in the bilateral\u2010HI group. This study suggests the possibility of using pre\u2010 and intraoperative observation of CP origin to predict four HI patterns and even subsequent outcomes after tumor removal.<\/jats:p>","DOI":"10.1002\/cam4.3589","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T09:59:55Z","timestamp":1604397595000},"page":"8950-8961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Hypothalamic injury patterns after resection of craniopharyngiomas and correlation to tumor origin: A study based on endoscopic observation"],"prefix":"10.1002","volume":"9","author":[{"given":"Le","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShenHao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The 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