{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:31:03Z","timestamp":1787502663154,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Limited data are currently available on the outcome of patients with acute myeloid leukemia (AML) undergoing allogeneic stem cell transplantation (allo\u2010SCT) with a reduced performance status. We herein present the results of a registry study on 2,936 AML patients undergoing allo\u2010SCT in first remission (CR1) with a Karnofsky Performance Status (KPS) score less than or equal to 80%. Two\u2010year leukemia\u2010free survival (LFS), overall survival (OS) and graft\u2010versus\u2010host disease (GVHD)\u2010free, and relapse\u2010free survival (GRFS) rates were 54%, 59%, and 41%, respectively. In multivariable analysis, patients with a KPS score\u00a0=\u00a080% had lower non\u2010relapse mortality (NRM) and superior OS in comparison to patients with a KPS score\u00a0&lt;80% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). In the subgroup of patients with a KPS score\u00a0=80%, a reduced\u2010intensity conditioning (RIC) regimen was associated with an increased risk of relapse (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002) and lower GRFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) compared to myeloablative conditioning (MAC). Differently, in patients with a KPS score\u00a0&lt;80%, a RIC regimen resulted in lower NRM (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), whereas relapse incidence did not differ, thus leading to an improved GRFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.008) as compared to MAC. A transplant from a matched sibling donor (MSD) was associated with a reduced incidence of grade III\u2010IV acute GVHD (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01) and NRM (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01) in comparison to other donor types. In conclusion, allo\u2010SCT appears feasible in AML patients with a jeopardized KPS score. Survival is significantly affected by the conditioning intensity, which should be adjusted according to the severity of KPS impairment.\n                  <\/jats:p>","DOI":"10.1002\/cam4.3593","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T13:15:10Z","timestamp":1606396510000},"page":"23-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Allogeneic stem cell transplant in patients with acute myeloid leukemia and karnofsky performance status score less than or equal to 80%: A study from the acute leukemia working party of the European Society for Blood and Marrow Transplantation (EBMT)"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-9514","authenticated-orcid":false,"given":"Francesco","family":"Saraceni","sequence":"first","affiliation":[{"name":"Hematology and Stem Cell Transplant Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"EBMT Paris Study Office Saint Antoine Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Forcade","sequence":"additional","affiliation":[{"name":"CHU Bordeaux H\u00f4pital Haut\u2010leveque Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Centre University Hospital Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Department of Hematology \u2010 BMT Hopital St. Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riitta","family":"Niittyvuopio","sequence":"additional","affiliation":[{"name":"HUCH Comprehensive Cancer Center Stem Cell Transplantation Unit Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J.","family":"Cornelissen","sequence":"additional","affiliation":[{"name":"Department of Hematology Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Labussi\u00e8re\u2010Wallet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Lyon Sud Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Programme de Transplantation &amp; Therapie Cellulaire Centre de Recherche en Canc\u00e9rologie de Marseille Institut Paoli Calmettes Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goda","family":"Choi","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen (UMCG) Department of Hematology University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny L.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Nottingham University Nottingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Guillerm","sequence":"additional","affiliation":[{"name":"C.H.R.U de Brest Service Onco\u2010Hematologie Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Marchand","sequence":"additional","affiliation":[{"name":"Service d`Hematologie Clinique Adulte Centre Hospitalier Universitaire de Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Esteve","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona 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as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC\u2010FludT.14\/L): a randomised, non\u2010inferiority, phase 3 trial","volume":"7","author":"Beelen DW","year":"2020","journal-title":"Lancet Haematol"},{"key":"e_1_2_9_22_1","first-page":"105","article-title":"Safety and efficacy of haploidentical peripheral blood stem cell transplantation for myeloid malignancies using post\u2010transplantation cyclophosphamide and anti\u2010thymocyte globulin as graft\u2010versus\u2010host disease prophylaxis","volume":"2","author":"Salas MQ","year":"2019","journal-title":"Clin Hematol 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