{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:22Z","timestamp":1786977322292,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Functional and QoL outcomes were compared longitudinally in a cohort of patients treated for oropharyngeal squamous cell carcinoma (OPSCC) with primary transoral robotic surgery (TORS) or radiotherapy (RT). Forty\u2010four patients undergoing primary TORS (n\u00a0=\u00a031) or RT (n\u00a0=\u00a013) for any stage OPSCC were included. Only low\u2010stage disease was treated with TORS. Functional outcomes were: salivary flow rate, image\u2010based swallowing function, and a self\u2010reported 10\u2010point scale comparing current swallowing function to baseline (CvB scale). QoL was assessed with European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ\u2010C30), Head &amp; Neck Module (EORTC QLQ\u2010HN35), and MD Anderson Dysphagia Inventory (MDADI). Shoulder impairment was assessed with Neck Dissection Impairment Index (NDII) and Oxford Shoulder Score (OSS). In the RT group, salivary flow rates had significantly declined at 12\u2010month follow\u2010up, with the biggest declines in QoL subscale scores recorded in the RT group for dry mouth and sticky saliva. Swallowing function on imaging studies was overall good, with no severe dysphagia within 1\u00a0year although, both treatment groups showed significant deterioration relative to baseline at the 12\u2010month follow\u2010up with increased DIGEST scores and pharyngeal retention. Shoulder impairment was rare at 1\u00a0year in both groups. A comprehensive examination of this cohort treated for OPSCC showed overall good functional and QoL outcomes 1\u00a0year after treatment. However, persistent impairment was seen in both groups with regards to swallowing function. In the TORS group, at 12\u2010months follow\u2010up, the QoL questionnaires showed worse scores in only one subscale (sticky saliva).<\/jats:p>","DOI":"10.1002\/cam4.3599","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T01:29:22Z","timestamp":1607131762000},"page":"483-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Long\u2010term quality of life &amp; functional outcomes after treatment of oropharyngeal cancer"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1197-2641","authenticated-orcid":false,"given":"Susanne I.","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery &amp; Audiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kathrine \u00d8. Madsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery &amp; Audiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niclas","family":"Rubek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery &amp; Audiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte W.","family":"Charabi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery &amp; Audiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Wessel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery &amp; Audiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-4337","authenticated-orcid":false,"given":"Sara","family":"Fredslund Hadj\u00fa","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy and Physiotherapy, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"},{"name":"Cancer Late Effects Research Unit (CASTLE) Department of Oncology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus V.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Stephen","sequence":"additional","affiliation":[{"name":"Department of Speech, Voice and Swallow ENT Freeman Hospital Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"Patterson","sequence":"additional","affiliation":[{"name":"School of Health Sciences \/ Head and Neck Cancer Centre University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe","family":"Friborg","sequence":"additional","affiliation":[{"name":"Department of Oncology, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine A.","family":"Hutcheson","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Division of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Kehlet","sequence":"additional","affiliation":[{"name":"Section for Surgical Pathophysiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6753-8129","authenticated-orcid":false,"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery &amp; Audiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.04.027"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.1106"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24712"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.1166"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2011.05.008"},{"issue":"66","key":"e_1_2_9_8_1","first-page":"648","article-title":"Physiological factors affecting salivary flow rate, oral sugar clearance, and the sensation of dry mouth in man","volume":"1987","author":"Dawes C","year":"1967","journal-title":"J Dent Res"},{"key":"e_1_2_9_9_1","unstructured":"LamP CicheroJ ChenJ et al.Complete IDDSI Framework Detailed definitions;2017."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30283"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-015-9631-4"},{"issue":"7","key":"e_1_2_9_12_1","first-page":"870","article-title":"The development and validation of a dysphagia\u2010specific quality\u2010of\u2010life questionnaire for patients with head and neck cancer: the M. 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