{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:46:29Z","timestamp":1780602389264,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773555"],"award-info":[{"award-number":["81773555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472971"],"award-info":[{"award-number":["81472971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The stage\u2010specific roles of radiotherapy (RT) alone, chemotherapy alone, and combined RT and chemotherapy (CRT) for patients with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) have not been adequately evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed patients with all stages of NLPHL enrolled in the Surveillance, Epidemiology, and End Results (SEER) registry from January 2000 to December 2015. Propensity score (PS) analysis with 1:1 matching (PSM) was performed to ensure the well\u2010balanced characteristics of the comparison groups. Kaplan\u2013Meier and Cox proportional\u2010hazards models were used to evaluate the overall survival (OS), cancer\u2010specific survival (CSS), hazard ratios (HRs), and corresponding 95% confidence intervals (95% CI). Restricted mean survival times (RMST) were also used for the survival analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For early\u2010stage patients, CRT was associated with the best survival, the mean OS was significantly improved by approximately 20\u00a0months (20\u00a0m), and the risk of death was reduced by more than 80%, both before and after PSM (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). For advanced\u2010stage patients, none of RT alone, chemotherapy alone, or CRT had a significant effect on survival. Chemotherapy alone and CRT might be more beneficial for long\u2010term survival (RMST<jats:sub>120\u00a0m<\/jats:sub>: neither RT nor chemotherapy vs. chemotherapy alone vs. CRT\u00a0=\u00a0104\u00a0m vs. 111\u00a0m vs. 108\u00a0m). Subgroup analysis of patients with early\u2010stage NLPHL showed that CRT was associated with better survival of elderly patients (improved OS\u00a0=\u00a043.8\u00a0m, HR\u00a0=\u00a00.14, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). However, the survival benefits of treatments for young patients were not statistically significant. The efficacy of RT was significantly different between the age groups (<jats:italic>p<\/jats:italic><jats:sub>for interaction<\/jats:sub>\u00a0=\u00a00.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results from SEER data suggest that CRT may be considered for early\u2010stage NLPHL, especially for elderly patients. Further studies are needed to identify effective treatments in patients with advanced\u2010stage NLPHL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3620","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T06:50:22Z","timestamp":1606632622000},"page":"540-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The stage\u2010specific roles of radiotherapy and chemotherapy in nodular lymphocyte predominant Hodgkin lymphoma patients: a propensity score\u2010matched analysis of the SEER database"],"prefix":"10.1002","volume":"10","author":[{"given":"Shijie","family":"Wang","sequence":"first","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfang","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Health Management Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianglong","family":"Han","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejie","family":"Huang","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Qiao","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2416-9591","authenticated-orcid":false,"given":"Zhenming","family":"Fu","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.8869"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0099"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.9516"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2578-6"},{"key":"e_1_2_9_7_1","unstructured":"Nation Comprehensive Cancer Network (NCCN).Clinical pratice guidelines in oncology Hodgkin lymphoma vesion 2.2020."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2017.09.013"},{"issue":"12","key":"e_1_2_9_9_1","first-page":"1117","article-title":"The surveillance, epidemiology, and end results program: a national resource","volume":"8","author":"Hankey BF","year":"1999","journal-title":"Cancer Epidemiol, Biomark Prev"},{"key":"e_1_2_9_10_1","article-title":"WHO classification of tumours of haematopoietic and lymphoid tissues. 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