{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:01:48Z","timestamp":1785178908719,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sinonasal papillomas are characterized by their potential for frequent recurrences and malignant progression. Currently, the role of human papillomavirus (HPV) infection in sinonasal papillomas is unclear. A study was conducted to elucidate the impact of HPV infection on recurrence and malignant progression of sinonasal papillomas. One hundred and seven patients with 151 tumors could be examined. One hundred and one patients suffered from benign papilloma, mostly inverted papillomas (IP); six patients suffered from carcinomas in situ and squamous cell carcinomas (SCC) ex\u2010IP. Recurrent IP were more often HPV\u2010positive than non\u2010recurrent tumors (38.8% vs. 60%\u201365%). Low\u2010risk (LR) HPV infection (especially HPV 6) increased the risk of tumor recurrences (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0385 and<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0556, respectively). IP and oncocytic papillomas (both lesions are known for their malignant potential) were more often high\u2010risk (HR) HPV\u2010positive (15.5% and 16.7%) than fungiform papilloma (which usually does not progress to carcinoma). CIS and SCC ex\u2010IP displayed higher HPV rates than benign IP (83.3% vs. 38.8%), especially higher rates of HR\u2010HPV (66.7% vs. 23.8%,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0415). Data from this study endorse the hypothesis that recurrence of sinonasal papillomas is promoted by LR\u2010HPV infection and that malignant progression of IP is promoted by HR\u2010HPV infection.<\/jats:p>","DOI":"10.1002\/cam4.3642","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:31:18Z","timestamp":1608683478000},"page":"634-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of human papillomaviruses (HPV) on recurrence rate and malignant progression of sinonasal papillomas"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-0737","authenticated-orcid":false,"given":"Anja","family":"Paehler vor der Holte","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Nordstadt Clinic Academic Hospital Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Fangk","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Nordstadt Clinic Academic Hospital Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Glombitza","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology Nordstadt Clinic Academic Hospital Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Wilkens","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology Nordstadt Clinic Academic Hospital Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-0903","authenticated-orcid":false,"given":"Hans J.","family":"Welkoborsky","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Nordstadt Clinic Academic Hospital Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3904"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05747-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880524"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874357901105010080"},{"key":"e_1_2_7_6_1","first-page":"6132","article-title":"Detection of high\u2010risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes","volume":"24","author":"Klaes R","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_7_8_1","first-page":"563","article-title":"The spectrum of cervical diseases induced by low\u2010risk and undefined\u2010risk HPVS: Implications for Patient Management","volume":"1","author":"Varnai AD","year":"2007","journal-title":"Anticancer Res"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.03.030"},{"key":"e_1_2_7_11_1","article-title":"Warts (non\u2010genital)","volume":"12","author":"Loo SKF","year":"2014","journal-title":"BMJ Clin Evidence"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1517\/17530059.2.1.11"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-008-0048-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-45-3-162"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065898780182499"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21524"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23864"},{"key":"e_1_2_7_18_1","first-page":"709","article-title":"Significance of human papillomavirus in sinonasal papillomas","volume":"9","author":"Kraft M","year":"2001","journal-title":"J Laryngol Otol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21358"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1139-1"},{"key":"e_1_2_7_21_1","unstructured":"BehringerS.Das invertierte Papillom der Nase und Nasennebenh\u00f6hlen. 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