{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:45:31Z","timestamp":1790469931125,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T00:00:00Z","timestamp":1608854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are limited data on the prevalence of Lynch syndrome (LS) in women with primary ovarian cancer with mismatch repair deficiency (MMR\u2010D) by immunohistochemistry (IHC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Three hundred and eight cases of primary ovarian, fallopian, and peritoneal cancer between January 2012 and December 2019 were evaluated for MMR\u2010D by IHC. The incidence of LS in this cohort was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MMR\u2010D by IHC was identified in 16 of 308 (5.2%) (95% CI: 3.2%\u20138.3%) primary ovarian\u2010related cancers. Most cases with MMR\u2010D were endometrioid (<jats:italic>n<\/jats:italic>\u00a0=\u00a011, 68.7%); (95% CI: 44.2%\u201386.1%). MSH2\/MSH6 protein loss was detected in eight cases (50.0%); (95% CI: 28.0%\u201372.0%) and MLH1\/PMS2 protein loss was detected in four cases (25.0%); (95% CI: 9.7%\u201350.0%). MSH6 protein loss was detected in two cases (12.5%); (95% CI: 2.2%\u201337.3%) and PMS2 protein loss was detected in two cases (12.5%); (95% CI: 2.2%\u201337.3%). All four cases with MLH1\/PMS2 protein loss had <jats:italic>MLH1<\/jats:italic> promotor hypermethylation. All 12 women with ovarian cancer suggestive of LS underwent germline testing and 8 (66.6%); (95% CI: 38.8%\u201386.5%) were confirmed to have LS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most ovarian cancers with somatic MMR\u2010D were confirmed to have LS in this cohort. Germline testing for LS in addition to <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> for all women with an epithelial ovarian cancer would be efficient and would approach 100% sensitivity for identifying Lynch syndrome. Utilization of a multigene panel should also be considered, given the additional non\u2010Lynch germline mutation identified in this cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3688","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T05:32:35Z","timestamp":1608960755000},"page":"1012-1017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence of Lynch syndrome in women with mismatch repair\u2010deficient ovarian cancer"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-4079","authenticated-orcid":false,"given":"Rachel","family":"Hodan","sequence":"first","affiliation":[{"name":"Cancer Genetics and Genomics Stanford Health Care Stanford CA USA"},{"name":"Department of Pediatrics (Genetics) Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1278-9128","authenticated-orcid":false,"given":"Kerry","family":"Kingham","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Genomics Stanford Health Care Stanford CA USA"},{"name":"Department of Pediatrics (Genetics) Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Cotter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Genetics) Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann K.","family":"Folkins","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6175-9470","authenticated-orcid":false,"given":"Allison W.","family":"Kurian","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Genomics Stanford Health Care Stanford CA USA"},{"name":"Department of Oncology Stanford University School of Medicine Stanford CA USA"},{"name":"Department of Epidemiology and Population Health Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2513-7025","authenticated-orcid":false,"given":"James M.","family":"Ford","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Genomics Stanford Health Care Stanford CA USA"},{"name":"Department of Oncology Stanford University School of Medicine Stanford CA USA"},{"name":"Department of Genetics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teri","family":"Longacre","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012242"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70265-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0596-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.452"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31816380c4"},{"issue":"11","key":"e_1_2_9_7_1","first-page":"4963","article-title":"Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer","volume":"32","author":"Coppola D","year":"2012","journal-title":"Anticancer Res"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2013.0393"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000602"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00283"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.12.031"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053493"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2018.29.e29"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2015.12.013"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.09.030"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.01.537"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0644"},{"key":"e_1_2_9_18_1","unstructured":"National Comprehensive Cancer Network. 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