{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:21:46Z","timestamp":1779931306775,"version":"3.53.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Home\u2010based chemotherapy (HC) is a new treatment alternative to hospital\u2010based chemotherapy treatment (IP) and is administered via portable intravenous pumps at the patient's home. HC reduces the demand for inpatient bed capacity in hospitals and reduces the cost of an infusion. This study takes a societal perspective while conducting the cost\u2010utility and budget impact analyses (BIA) of HC and IP with an mFOLFOX6 regimen on patients with stage III colon cancer. We conducted a cost\u2010utility analysis with a 6\u2010month time horizon. The parameter inputs for the model were gathered from a retrospective cohort study on patients diagnosed with stage III colon cancer at Ramathibodi Hospital, Bangkok. The resource usage of HC and IP was determined based on medical records. The per\u2010unit direct medical, home health service, and adverse events (AE) management costs were gathered from the standard cost list. The health outcome of treatment was measured in terms of quality\u2010adjusted life years. Disutility related to AE was calculated. We conducted a sensitivity analysis for the uncertainty results and performed BIA based on the societal perspective on a 1\u2010year time horizon. HC provided a cost\u2010saving of $1,513.37 per patient for the period of treatment. Thus, assuming 526 patients per year, the use of HC could achieve a cumulative annual cost\u2010saving of $828,436. HC is a cost\u2010saving strategy compared to IP for stage III colon cancer treatment. We recommend that the service reimbursement should include national standardization in chemotherapy regimens as well as practice guidelines and protocols to prevent serious AEs.<\/jats:p>","DOI":"10.1002\/cam4.3690","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T21:12:30Z","timestamp":1609362750000},"page":"1027-1033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Home\u2010based chemotherapy for stage III colon cancer patients in Thailand: Cost\u2010utility and budget impact analyses"],"prefix":"10.1002","volume":"10","author":[{"given":"Nattanichcha","family":"Kulthanachairojana","sequence":"first","affiliation":[{"name":"Department of Social and Administrative Pharmacy Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phichai","family":"Chansriwong","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nintita Sripaiboonkij","family":"Thokanit","sequence":"additional","affiliation":[{"name":"Ramathibodi Comprehensive Cancer Center Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwannee","family":"Sirilerttrakul","sequence":"additional","affiliation":[{"name":"Department of Nursing Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nopakan","family":"Wannakansophon","sequence":"additional","affiliation":[{"name":"Department of Nursing Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0620-0762","authenticated-orcid":false,"given":"Suthira","family":"Taychakhoonavudh","sequence":"additional","affiliation":[{"name":"Department of Social and Administrative Pharmacy Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9080108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004479-200304000-00006"},{"key":"e_1_2_9_4_1","volume-title":"Protocol for the reimbursement of treatment for colon cancer in Thailand","year":"2013"},{"key":"e_1_2_9_5_1","volume-title":"National Health Security Office (NHSO)","year":"2018"},{"key":"e_1_2_9_6_1","unstructured":"Home chemotherapy administration by central venous system (Home 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