{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:20:15Z","timestamp":1792686015673,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2015CFB379"],"award-info":[{"award-number":["2015CFB379"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972565"],"award-info":[{"award-number":["81972565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472886"],"award-info":[{"award-number":["81472886"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Adenoid cystic carcinoma (ACC) is a distinctive tumour. Limited studies involving a large population have reported multicentre systematic analyses of the clinical, pathological and immunohistochemical (IHC) features of ACC as well as the potential role of IHC markers in the prognosis of ACC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The clinical, histopathological and IHC data of 296 cases obtained from two tertiary hospitals were analysed. The age at onset ranged from 12 to 87\u00a0years with a median age of 52\u00a0years. The male\u2010to\u2010female ratio was 1:1.3. Patients with ACC arising from the lacrimal gland were younger than those with tumours arising from other sites. Patients with tumours in the extra auditory canal and nasopharynx were older than those with tumours in other locations. Histopathologically, solid type ACC was the most frequent in the nasal cavity and paranasal sinus (6\/51) group. Tumours arising from the oral cavity most commonly showed perineural invasion (10\/60) and margin positivity (11\/60). IHC analyses showed that CK8\/18, CK7, CK14, epithelial membrane antigen and CD117 were expressed in 35\/35 (100%), 87\/88 (98.8%), 26\/27 (96.2%), 42\/43 (97.6%) and 113\/120 (94.1%) patients, respectively. CK5\/6, P63, smooth muscle actin, calponin and S100 were positively expressed in 73\/73 (100%), 111\/124 (89.5%), 38\/43 (88.3%), 41\/50 (82.0%) and 61\/92 (66.3%) cases, respectively. S100 proteins were expressed in 54 (54\/77) primary cases and two (2\/9) metastatic cases (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ACC is a distinctive tumour that mainly affects middle\u2010aged and elderly individuals, with a mild female predominance. Loss of expression of S100 proteins may be a poor prognostic factor associated with metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3707","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:07:20Z","timestamp":1610755640000},"page":"1120-1127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Multicentre clinicopathological study of adenoid cystic carcinoma: A report of 296 cases"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-2981","authenticated-orcid":false,"given":"Zheng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pathology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaorong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology &amp; Embryology Basic Medical College Hubei University of Traditional Chinese Medicine Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Pathology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"642","article-title":"Incidence of adenoid cystic carcinoma in nova scotia:30\u2010year population\u2010based epidemiologic study","volume":"37","author":"Bonaparte JP","year":"2008","journal-title":"J Otolaryngol Head and Neck Surg"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27408"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.22"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2016.03.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0487-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)00062-M"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0426-3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11288"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5076"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0005-y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-007-0032-3"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04095.x"},{"issue":"6","key":"e_1_2_10_14_1","first-page":"2793","article-title":"Estrogen enhances malignant phenotypes in human salivary adenoid cystic carcinoma cells","volume":"36","author":"Sumida T","year":"2016","journal-title":"Anticancer Res"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0377-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100139684"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12184"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-019-1110-5"},{"issue":"3","key":"e_1_2_10_19_1","first-page":"234","article-title":"Primary adenoid cystic carcinoma of the nasopharynx and its relation to Epstein\u2010Barr infection","volume":"32","author":"He JH","year":"2003","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.11.1193"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.12.002"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116009373"},{"issue":"5","key":"e_1_2_10_23_1","first-page":"1579","article-title":"MYB promotes the growth and metastasis of salivary adenoid cystic carcinoma","volume":"54","author":"Xu LH","year":"2019","journal-title":"Int J Oncol"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.60973"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03645.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr459"},{"issue":"11","key":"e_1_2_10_27_1","first-page":"1949","article-title":"The human myoepithelial cell is a natural tumour suppressor","volume":"3","author":"Sternlicht MD","year":"1997","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.1.39"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1996.tb01730.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00352-1"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3707","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.3707","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:54:26Z","timestamp":1693554866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.3707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,15]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/cam4.3707"],"URL":"https:\/\/doi.org\/10.1002\/cam4.3707","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,15]]},"assertion":[{"value":"2020-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}